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Integrated Electrochemical Sensor Array for On-Line Monitoring of Yeast Fermentations
This paper describes the design, modeling, and experimental characterization of an electrochemical sensor array for on-line monitoring of fermentor conditions in both miniaturized cell assays and in industrial scale fermentations. The viable biomass concentration is determined from impedance spectro...
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| Published in: | Analytical chemistry (Washington) 2007-08, Vol.79 (15), p.5567-5573 |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a511t-4028cdfb77dc784691322eb75f12f0a69338890938e9db11ff686a2966593adc3 |
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| cites | cdi_FETCH-LOGICAL-a511t-4028cdfb77dc784691322eb75f12f0a69338890938e9db11ff686a2966593adc3 |
| container_end_page | 5573 |
| container_issue | 15 |
| container_start_page | 5567 |
| container_title | Analytical chemistry (Washington) |
| container_volume | 79 |
| creator | Krommenhoek, E. E Gardeniers, J. G. E Bomer, J. G Li, X Ottens, M van Dedem, G. W. K Van Leeuwen, M van Gulik, W. M van der Wielen, L. A. M Heijnen, J. J van den Berg, and A |
| description | This paper describes the design, modeling, and experimental characterization of an electrochemical sensor array for on-line monitoring of fermentor conditions in both miniaturized cell assays and in industrial scale fermentations. The viable biomass concentration is determined from impedance spectroscopy. As a miniaturized electrode configuration with high cell constant is applied, the spectral conductivity variation is monitored instead of the permittivity variation. The dissolved oxygen concentration is monitored amperometrically using an ultramicroelectrode array, which is shown to have negligible flow dependence. pH is monitored using an ion-sensitive field effect transistor (ISFET), and a platinum thermistor is included for temperature measurements. All sensors were shown to be sufficiently accurate within the range relevant to yeast fermentations. The sensor array is shown to be very stable and durable and withstands steam-sterilization. |
| doi_str_mv | 10.1021/ac0623078 |
| format | article |
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E ; Gardeniers, J. G. E ; Bomer, J. G ; Li, X ; Ottens, M ; van Dedem, G. W. K ; Van Leeuwen, M ; van Gulik, W. M ; van der Wielen, L. A. M ; Heijnen, J. J ; van den Berg, and A</creator><creatorcontrib>Krommenhoek, E. E ; Gardeniers, J. G. E ; Bomer, J. G ; Li, X ; Ottens, M ; van Dedem, G. W. K ; Van Leeuwen, M ; van Gulik, W. M ; van der Wielen, L. A. M ; Heijnen, J. J ; van den Berg, and A</creatorcontrib><description>This paper describes the design, modeling, and experimental characterization of an electrochemical sensor array for on-line monitoring of fermentor conditions in both miniaturized cell assays and in industrial scale fermentations. The viable biomass concentration is determined from impedance spectroscopy. As a miniaturized electrode configuration with high cell constant is applied, the spectral conductivity variation is monitored instead of the permittivity variation. The dissolved oxygen concentration is monitored amperometrically using an ultramicroelectrode array, which is shown to have negligible flow dependence. pH is monitored using an ion-sensitive field effect transistor (ISFET), and a platinum thermistor is included for temperature measurements. All sensors were shown to be sufficiently accurate within the range relevant to yeast fermentations. The sensor array is shown to be very stable and durable and withstands steam-sterilization.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac0623078</identifier><identifier>PMID: 17585833</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Analytical chemistry ; Biogas ; Biomass ; Biosensing Techniques - instrumentation ; Biosensing Techniques - methods ; Chemistry ; Electrochemistry ; Equipment Design ; Exact sciences and technology ; Fermentation ; General, instrumentation ; Hydrogen-Ion Concentration ; Industrial Microbiology ; Microelectrodes ; Platinum - chemistry ; Saccharomyces cerevisiae - cytology ; Saccharomyces cerevisiae - metabolism ; Sensitivity and Specificity ; Sensors ; Spectrum analysis ; Temperature ; Thermometers ; Transistors, Electronic ; Yeast</subject><ispartof>Analytical chemistry (Washington), 2007-08, Vol.79 (15), p.5567-5573</ispartof><rights>Copyright © 2007 American Chemical Society</rights><rights>2007 INIST-CNRS</rights><rights>Copyright American Chemical Society Aug 1, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a511t-4028cdfb77dc784691322eb75f12f0a69338890938e9db11ff686a2966593adc3</citedby><cites>FETCH-LOGICAL-a511t-4028cdfb77dc784691322eb75f12f0a69338890938e9db11ff686a2966593adc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18989863$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17585833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krommenhoek, E. E</creatorcontrib><creatorcontrib>Gardeniers, J. G. E</creatorcontrib><creatorcontrib>Bomer, J. G</creatorcontrib><creatorcontrib>Li, X</creatorcontrib><creatorcontrib>Ottens, M</creatorcontrib><creatorcontrib>van Dedem, G. W. K</creatorcontrib><creatorcontrib>Van Leeuwen, M</creatorcontrib><creatorcontrib>van Gulik, W. M</creatorcontrib><creatorcontrib>van der Wielen, L. A. M</creatorcontrib><creatorcontrib>Heijnen, J. J</creatorcontrib><creatorcontrib>van den Berg, and A</creatorcontrib><title>Integrated Electrochemical Sensor Array for On-Line Monitoring of Yeast Fermentations</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>This paper describes the design, modeling, and experimental characterization of an electrochemical sensor array for on-line monitoring of fermentor conditions in both miniaturized cell assays and in industrial scale fermentations. The viable biomass concentration is determined from impedance spectroscopy. As a miniaturized electrode configuration with high cell constant is applied, the spectral conductivity variation is monitored instead of the permittivity variation. The dissolved oxygen concentration is monitored amperometrically using an ultramicroelectrode array, which is shown to have negligible flow dependence. pH is monitored using an ion-sensitive field effect transistor (ISFET), and a platinum thermistor is included for temperature measurements. All sensors were shown to be sufficiently accurate within the range relevant to yeast fermentations. 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The viable biomass concentration is determined from impedance spectroscopy. As a miniaturized electrode configuration with high cell constant is applied, the spectral conductivity variation is monitored instead of the permittivity variation. The dissolved oxygen concentration is monitored amperometrically using an ultramicroelectrode array, which is shown to have negligible flow dependence. pH is monitored using an ion-sensitive field effect transistor (ISFET), and a platinum thermistor is included for temperature measurements. All sensors were shown to be sufficiently accurate within the range relevant to yeast fermentations. The sensor array is shown to be very stable and durable and withstands steam-sterilization.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>17585833</pmid><doi>10.1021/ac0623078</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Analytical chemistry (Washington), 2007-08, Vol.79 (15), p.5567-5573 |
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| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Analytical chemistry Biogas Biomass Biosensing Techniques - instrumentation Biosensing Techniques - methods Chemistry Electrochemistry Equipment Design Exact sciences and technology Fermentation General, instrumentation Hydrogen-Ion Concentration Industrial Microbiology Microelectrodes Platinum - chemistry Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Sensitivity and Specificity Sensors Spectrum analysis Temperature Thermometers Transistors, Electronic Yeast |
| title | Integrated Electrochemical Sensor Array for On-Line Monitoring of Yeast Fermentations |
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