Effect of docosahexaenoic acid on macrophage functions of rats

Abstract Docosahexaenoic acid (DHA) is an omega-3 fatty acid which has been demonstrated to exhibit anti-inflammatory effects. The objective of this study was to determine the effect of DHA on phagocytic and chemotactic activities of peritoneal macrophages obtained from rats. DHA was dissolved in 1...

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Bibliographic Details
Published in:Immunobiology (1979) 2007-01, Vol.212 (7), p.583-587
Main Authors: Bulbul, Mehmet, Tan, Ruken, Gemici, Burcu, Hacıoglu, Gülay, Agar, Aysel, Nimet Izgut-Uysal, V
Format: Article
Language:English
Subjects:
Advanced Basic Science
Allergy and Immunology
Animals
Chemotaxis
Chemotaxis - drug effects
Docosahexaenoic acid
Docosahexaenoic Acids - administration & dosage
Docosahexaenoic Acids - pharmacology
Macrophage
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Male
Phagocytosis
Phagocytosis - drug effects
Rats
Rats, Wistar
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Summary:Abstract Docosahexaenoic acid (DHA) is an omega-3 fatty acid which has been demonstrated to exhibit anti-inflammatory effects. The objective of this study was to determine the effect of DHA on phagocytic and chemotactic activities of peritoneal macrophages obtained from rats. DHA was dissolved in 1 ml of corn oil at dose of 36 mg/kg/day and given via oral gavage for 4 weeks. Control rats received 1 ml/day corn oil as vehicle. At the end of the treatment period, peritoneal macrophages were isolated and chemotactic and phagocytic activities were assayed. Chemotactic and phagocytic activities were reduced in rats fed with DHA. These results demonstrated the effect of DHA in modulating immune activities of rat peritoneal macrophages.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2007.04.004