Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: Is mucinous carcinoma a distinct histological entity?

Mucinous carcinoma of the colorectum is conventionally defined as carcinoma with an interstitial mucus component (MC) that occupies more than 50% of the tumor tissue. To examine the validity of this definition, we quantified the ratio between the area of MC and the total area of carcinoma (MC ratio)...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2007-01, Vol.203 (8), p.567-574
Main Authors: Tozawa, Erica, Ajioka, Yoichi, Watanabe, Hidenobu, Nishikura, Ken, Mukai, Gen, Suda, Takeyasu, Kanoh, Tsunehisa, Hatakeyama, Katsuyoshi
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - classification
Adenocarcinoma, Mucinous - immunology
Adenocarcinoma, Mucinous - metabolism
Biomarkers, Tumor - analysis
Colorectal carcinoma
Colorectal Neoplasms - classification
Colorectal Neoplasms - immunology
Colorectal Neoplasms - metabolism
Female
Humans
Immunohistochemistry
Lymphocytes, Tumor-Infiltrating - immunology
Male
Middle Aged
Mucin expression
Mucinous carcinoma
Mucins - biosynthesis
p53 overexpression
Peritumoral lymphocytic infiltration
Phenotype
Tumor Suppressor Protein p53 - biosynthesis
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Summary:Mucinous carcinoma of the colorectum is conventionally defined as carcinoma with an interstitial mucus component (MC) that occupies more than 50% of the tumor tissue. To examine the validity of this definition, we quantified the ratio between the area of MC and the total area of carcinoma (MC ratio) in 152 advanced colorectal carcinomas, and investigated whether MUC1, MUC2 and MUC5AC mucin expression, frequency of p53 overexpression, and peritumoral lymphocytic infiltration (PLI) of tumors differ in the MC ratio. Samples were classified into MC ratios of >50% ( n=30), 10–50% ( n=24),
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2007.04.013