Quantitative Magnetic Resonance Perfusion Imaging Detects Anatomic and Physiologic Coronary Artery Disease as Measured by Coronary Angiography and Fractional Flow Reserve

• Published in: Journal of the American College of Cardiology 2007-08, Vol.50 (6), p.514-522
• Main Authors: Costa, Marco A., MD, PhD, FACC, Shoemaker, Steven, MD, Futamatsu, Hideki, MD, PhD, Klassen, Chris, MD, Angiolillo, Dominick J., MD, PhD, FACC, Nguyen, Minh, MD, Siuciak, Alan, MS, Gilmore, Paul, MD, FACC, Zenni, Martin M., MD, FACC, Guzman, Luis, MD, FACC, Bass, Theodore A., MD, FACC, Wilke, Norbert, MD, FACC
• Format: Article
• Language: English
• Subjects: Aged; Anatomy & physiology; Automation; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular system; Coronary Angiography; Coronary Artery Disease - diagnosis; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - physiopathology; Coronary heart disease; Coronary Stenosis - diagnosis; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - physiopathology; Coronary vessels; Female; Fractional Flow Reserve, Myocardial - physiology; Heart; Heart attacks; Humans; Internal Medicine; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Male; Medical imaging; Medical sciences; Methods; Middle Aged; Prospective Studies; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Studies
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.04.053

Quantitative Magnetic Resonance Perfusion Imaging Detects Anatomic and Physiologic Coronary Artery Disease as Measured by Coronary Angiography and Fractional Flow Reserve Marco A Costa, Steven Shoemaker, Hideki Futamatsu, Chris Klassen, Dominick J Angiolillo, Minh Nguyen, Alan Siuciak, Paul Gilmore, Martin M Zenni, Luis Guzman, Theodore A Bass, Norbert Wilke This prospective study tested the ability of myocardial perfusion reserve (MPR) based on magnetic resonance perfusion imaging (CMR) to assess the physiologic significance of coronary artery disease (CAD) compared with well-established anatomic and physiologic techniques. Thirty-seven patients with suspected CAD underwent coronary angiography, fractional flow reserve (FFR), and CMR assessments. An MPR cutoff of 2.04 had 92.9% sensitivity, 56.7% specificity, and 0.94 negative predictive value (NPV) in predicting ≤0.75 FFR. An MPR cutoff of 2.04 had 85.1% sensitivity, 49.2% specificity, and 0.83 NPV in predicting a ≥50% angiographic diameter stenosis. Quantitative perfusion CMR is an alternative and noninvasive stenosis-specific test to evaluate for hemodynamically significant CAD.