Differential Effects of Ramipril on Ambulatory Blood Pressure in African Americans and Caucasians

• Published in: American journal of hypertension 2007-08, Vol.20 (8), p.884-891
• Main Authors: Moran, Andrew, Simon, Joel A., Shiboski, Stephen, Pickering, Thomas G., Waters, David, Rotter, Jerome I., Lyon, Christopher, Nickerson, Deborah, Yang, Huiying, Saad, Mohammed, Hsueh, Willa, Krauss, Ronald M.
• Format: Article
• Language: English
• Subjects: African American; African Americans; Ambulatory blood pressure; angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive agents; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Cardiology. Vascular system; Cardiovascular system; Caucasian; Circadian Rhythm - physiology; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Dose-Response Relationship, Drug; European Continental Ancestry Group; Female; Follow-Up Studies; Humans; Hypertension - drug therapy; Hypertension - ethnology; Hypertension - physiopathology; Male; Medical sciences; Middle Aged; nondipping; Pharmacology. Drug treatments; pharmacotherapy; Prospective Studies; Ramipril - administration & dosage; Ramipril - therapeutic use; Treatment Outcome; United States - epidemiology
• ISSN: 0895-7061; 1879-1905; 1941-7225
• DOI: 10.1016/j.amjhyper.2007.02.006

On average, angiotensin-converting enzyme inhibitors produce less office blood-pressure lowering in African Americans compared with Caucasians. Past studies did not compare daytime and nighttime ambulatory blood-pressure responses to angiotensin-converting enzyme inhibitors in African Americans and Caucasians. We measured the office and ambulatory blood-pressure response to 8 weeks of a fixed dose of 10 mg daily of the angiotensin-converting enzyme inhibitor ramipril in a cohort of 72 African Americans and 89 Caucasians. Ramipril lowered age-adjusted daytime ambulatory systolic blood pressure 6 mm Hg and diastolic blood pressure 3 mm Hg less in African Americans compared with Caucasians (both P = .02). This difference persisted after adjusting for baseline blood pressure, body mass index, urine sodium and potassium, plasma aldosterone, and other covariates. Despite the difference in mean response, there was a 72% overlap in daytime blood-pressure response to ramipril between African Americans and Caucasians. Among Caucasians, ramipril lowered systolic blood pressure 2 mm Hg less during nighttime compared with daytime, whereas among African Americans, blood pressure lowering was equivalent during day and night. Nighttime blood-pressure response to ramipril did not differ significantly between African Americans and Caucasians. Ramipril was more effective in lowering daytime blood pressure in Caucasians compared with African Americans, but appreciable differences in response did not persist at night. Despite the small difference in mean response between groups, the majority of African Americans and Caucasians had a similar blood-pressure response to a fixed dose of ramipril.