Vaccine manufacturing: challenges and solutions

The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, develop...

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Bibliographic Details
Published in:Nature biotechnology 2006-11, Vol.24 (11), p.1377-1383
Main Authors: Ulmer, Jeffrey B, Valley, Ulrich, Rappuoli, Rino
Format: Article
Language:English
Subjects:
Agriculture
Bioinformatics
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Biotechnology - trends
Costs and Cost Analysis
Drug Delivery Systems - methods
Drug Delivery Systems - trends
Drug Industry - economics
Drug Industry - methods
Drug Industry - trends
Fundamental and applied biological sciences. Psychology
Funding
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Infectious diseases
Influenza
Influenza, Human - prevention & control
Life Sciences
perspective
Production of active biomolecules
R&D
Regulation
Research & development
Technology, Pharmaceutical - economics
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - trends
Vaccines
Vaccines - biosynthesis
Vaccines - chemical synthesis
Vaccines - economics
Vaccines - supply & distribution
Vaccins
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Summary:The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, development and production of vaccines has the potential to prevent such occurrences and enable the introduction of new vaccines. Gene-based vaccines, virus-like particles, plant-derived vaccines and novel adjuvants and delivery systems represent promising approaches to creating safer, more potent vaccines. As a consequence, more people will have faster access to more effective vaccines against a broader spectrum of infectious diseases. However, the increased cost of producing new vaccines and regulatory uncertainty remain challenges for vaccine manufacturers.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt1261