Stretching of proteins in a uniform flow

Stretching of a protein by a fluid flow is compared to that in a force-clamp apparatus. The comparison is made within a simple topology-based dynamical model of a protein in which the effects of the flow are implemented using Langevin dynamics. We demonstrate that unfolding induced by a uniform flow...

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Published in:The Journal of chemical physics 2006-10, Vol.125 (16), p.164903-164903-8
Main Authors: Szymczak, P., Cieplak, Marek
Format: Article
Language:English
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Models, Biological
Protein Folding
Proteins - chemistry
Proteins - metabolism
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description Stretching of a protein by a fluid flow is compared to that in a force-clamp apparatus. The comparison is made within a simple topology-based dynamical model of a protein in which the effects of the flow are implemented using Langevin dynamics. We demonstrate that unfolding induced by a uniform flow shows a richer behavior than that in the force clamp. The dynamics of unfolding is found to depend strongly on the selection of the amino acid, usually one of the termini, which is anchored. These features offer potentially wider diagnostic tools to investigate structure of proteins compared to experiments based on the atomic force microscopy.
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subjects Models, Biological
Protein Folding
Proteins - chemistry
Proteins - metabolism
title Stretching of proteins in a uniform flow
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