Allergic eosinophilic esophagitis

Allergic eosinophilic esophagitis is an increasingly recognized disease in various parts of the world. The clinical presentation mimics other gastrointestinal diseases, especially gastroesophageal reflux disease, making endoscopic examination and histological evaluation of esophageal mucosal biopsie...

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Bibliographic Details
Published in:Indian journal of pediatrics 2006-10, Vol.73 (10), p.919-925
Main Authors: Bax, Kevin C, Gupta, Sandeep K
Format: Article
Language:English
Subjects:
Child
Endoscopy, Digestive System
Eosinophilia - physiopathology
Esophageal pH Monitoring
Esophagitis - diagnosis
Esophagitis - physiopathology
Esophagitis - therapy
Humans
Hypersensitivity - complications
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Summary:Allergic eosinophilic esophagitis is an increasingly recognized disease in various parts of the world. The clinical presentation mimics other gastrointestinal diseases, especially gastroesophageal reflux disease, making endoscopic examination and histological evaluation of esophageal mucosal biopsies crucial to accurate diagnosis. The pathogenesis likely involves allergen-initiated, TH2-dependent, IL-5 mediated infiltration of eosinophilis into the esophageal mucosa. Therapies currently favored include dietary modifications and use of corticosteroids.
ISSN:0019-5456
0973-7693
DOI:10.1007/bf02859286