Vacuum-assisted breast biopsy: The value and limitations of cores with microcalcifications

The aim of this study was to assess cores with microcalcifications (CM) and without microcalcifications (CWM) obtained from vacuum-assisted breast biopsy (VABB). The study included 12 atypical ductal hyperplasias (ADH), 37 ductal carcinomas in situ (DCIS), and seven invasive ductal carcinomas (IDC)...

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Published in:Pathology, research and practice research and practice, 2007-01, Vol.203 (8), p.563-566
Main Authors: Zagouri, Flora, Sergentanis, Theodoros N., Nonni, Afroditi, Koulocheri, Dimitra, Fotou, Maria, Panopoulou, Effrosyni, Panou, Marios, Fotiadis, Constantine, Bramis, John, Zografos, George C.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biopsy - methods
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Calcinosis - pathology
Calcinosis - surgery
Cores
Female
Humans
Microcalcifications
Middle Aged
Precancerous Conditions - pathology
Precancerous Conditions - surgery
Retrospective Studies
Underestimation
Vacuum
Vacuum-assisted breast biopsy
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Summary:The aim of this study was to assess cores with microcalcifications (CM) and without microcalcifications (CWM) obtained from vacuum-assisted breast biopsy (VABB). The study included 12 atypical ductal hyperplasias (ADH), 37 ductal carcinomas in situ (DCIS), and seven invasive ductal carcinomas (IDC) diagnosed by VABB (11 G) on the Fischer's table. More than 24 cores were excised. For CM/CWM, a separate pathology report was given. Open surgery followed, and underestimation was calculated. The CM/CWM discrepancy was evaluated (superiority, identity, and inferiority). CWM failed to make the diagnosis in 8.3% and 35.1% of ADH and DCIS, respectively. In 28.6% of IDC, diagnosis was made through CWM. CM volume was 1.2±0.3 cm 3 for the two IDCs missed by CM, 1.0±0.4 cm 3 for the 40 cases of identical diagnoses, and 1.4±0.5 cm 3 for the 14 cases of CM superiority ( p=0.048, Kruskal–Wallis test). CWM volume was 6.3±1.8 cm 3 for the two IDCs missed by CM, 2.6±1.8 cm 3 for cases with identical diagnoses, and 3.4±1.6 cm 3 for cases of CM superiority ( p=0.018, Kruskal–Wallis test). The underestimation rate was 8.3% in ADH, and 10.8% in DCIS. CMs are superior in DCIS/ADH diagnosis. However, CWM may be valuable for the diagnosis of the invasive component.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2007.05.001