Clinical Significance of Tissue Expression of Interleukin-6 in Colorectal Carcinoma

Background: Although serum interleukin-6 (IL-6) has been associated with the development of colorectal cancer, IL-6 expression in cancer tissues has never been elucidated. The role of the tissue expression of IL-6 in colorectal cancer was investigated to identify any prognostic significance. Materia...

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Bibliographic Details
Published in:Anticancer research 2006-09, Vol.26 (5B), p.3905-3911
Main Authors: CHUNG, Yuan-Chiang, CHAEN, Yuan-Liang, HSU, Chi-Pin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Colorectal Neoplasms - metabolism
Enzyme-Linked Immunosorbent Assay
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Interleukin-6 - metabolism
Male
Medical sciences
Middle Aged
Prognosis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Background: Although serum interleukin-6 (IL-6) has been associated with the development of colorectal cancer, IL-6 expression in cancer tissues has never been elucidated. The role of the tissue expression of IL-6 in colorectal cancer was investigated to identify any prognostic significance. Materials and Methods: One hundred and sixty consecutive patients, whose primary lesions had been resected, were studied. Immunoreactivity of IL-6 in cancerous tissue was measured by immunohistochemical staining; the relationships between the positive expression of IL-6 and both clinicopathological factors and survival were evaluated. Results: Seventy-four specimens expressed IL-6, and this expression correlated with an elevated serum carcinoembryonic antigen level, lymph node metastasis, venous invasion and advanced stage (p
ISSN:0250-7005
1791-7530