Immunohistochemical Evaluation of Minichromosome Maintenance Protein 7 in Astrocytoma Grading

The minichromosome maintenance (MCM) proteins, which play an important role in eukaryotic DNA replication, represent a group of proteins that are currently under investigation as novel diagnostic tumor markers. Several studies have proved a greater reliability of MCM proteins to stain proliferating...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2006-09, Vol.26 (5A), p.3513-3516
Main Authors: FACOEITI, A, RANZA, E, GRECCHI, I, BENERICETTI, E, CERONI, M, MORBINI, P, NANO, R
Format: Article
Language:English
Subjects:
Astrocytoma - metabolism
Astrocytoma - pathology
Biological and medical sciences
Cell Cycle Proteins - metabolism
DNA-Binding Proteins - metabolism
Humans
Immunoenzyme Techniques
Ki-67 Antigen - metabolism
Medical sciences
Minichromosome Maintenance Complex Component 7
Neoplasm Staging
Neurology
Nuclear Proteins - metabolism
Prognosis
Proliferating Cell Nuclear Antigen - metabolism
Tumors
Tumors of the nervous system. Phacomatoses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The minichromosome maintenance (MCM) proteins, which play an important role in eukaryotic DNA replication, represent a group of proteins that are currently under investigation as novel diagnostic tumor markers. Several studies have proved a greater reliability of MCM proteins to stain proliferating cells compared to Ki67 protein, a routinely used proliferation marker in histopathology. In the present study, the expressions of MCM7 and Ki67 were estimated in 66 primary human astrocytomas in relation to tumor grade (Grade I-IV, WHO). MCM7 significantly stained more nuclei compared to Ki67 in all the histopathological grades investigated. In addition, a stronger increase of the MCM7 labelling index, in relation to the tumor aggressiveness, was observed.
ISSN:0250-7005
1791-7530