Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16– 20 exhibited mild activity.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-12, Vol.16 (23), p.6019-6023
Main Authors: Rajakumar, Perumal, Mohammed Abdul Rasheed, A., Iman Rabia, A., Chamundeeswari, D.
Format: Article
Language:English
Subjects:
Amides - chemical synthesis
Amides - chemistry
Amides - pharmacology
Anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cyclophane
Erythrocyte Membrane - drug effects
Erythrocytes - drug effects
Ethers, Cyclic - chemistry
HRBC stabilization
Humans
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Piperidines - chemistry
Structure-Activity Relationship
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Description
Summary:Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16– 20 exhibited mild activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.08.124