Intracellular magnesium in elderly patients with heart failure: Effects of diabetes and renal dysfunction

• Published in: Journal of trace elements in medicine and biology 2006-01, Vol.20 (4), p.221-226
• Main Authors: Alon, Irena, Gorelik, Oleg, Berman, Sylvia, Almoznino-Sarafian, Dorit, Shteinshnaider, Miriam, Weissgarten, Joshua, Modai, David, Cohen, Natan
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Case-Control Studies; Diabetes mellitus; Diabetes Mellitus - metabolism; Female; Heart Diseases - blood; Heart Diseases - etiology; Heart failure; Humans; Kidney Diseases - blood; Magnesium; Magnesium - blood; Male; Middle Aged; Renal failure
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2006.04.004

Hypomagnesemia is frequent in diabetes mellitus (DM), while renal dysfunction (RD) may be associated with hypermagnesemia. Severe cardiac arrhythmias and other adverse clinical manifestations are frequent in heart failure (HF), in DM and in RD. Depletion of intracellular magnesium (icMg), which may coexist with normal serum Mg, might contribute to these deleterious effects. However, icMg content in normomagnesemic HF patients with RD or DM has not been studied. We assessed total icMg in peripheral blood mononuclear cells (PBMC) from 80 normomagnesemic furosemide-treated HF patients who were divided as follows: subgroups A (DM), B (RD), C (DM and RD), and D (free of DM or RD). PBMC from 18 healthy volunteers served as controls. IcMg content (μg/mg cell protein) in HF was lower compared to controls (1.68±0.2 vs. 2.4±0.39, p