Lack of association between NOS3 Glu298Asp and breast cancer risk : a case-control study

Nitric oxide (NO) plays a central role in the physiololgy and pathology of diverse tissues. Different studies provide data suggesting that the endothelial cell nitric oxide synthase (NOS3) expression in peritumoral microvessels might be a prognostic indicator in breast cancer patients. However, the...

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Published in:Breast cancer research and treatment 2006-12, Vol.100 (3), p.331-333
Main Authors: ROYO, Jose Luis, MORENO-NOGUEIRA, José Andrés, GALAN, Jose Jorge, GONZALEZ-MARTIN, Antonio, RUIZ, Agustin, GONZALEZ-MANCHA, Rosario, REAL, Luis Miguel
Format: Article
Language:English
Subjects:
Aspartic Acid
Biological and medical sciences
Breast Neoplasms - enzymology
Breast Neoplasms - genetics
Case-Control Studies
Epidemiology
Female
Gene Expression Regulation, Neoplastic
Gene Frequency
General aspects
Genetic Predisposition to Disease
Glutamic Acid
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Nitric Oxide Synthase Type III - genetics
Odds Ratio
Polymorphism, Genetic
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Assessment
Risk Factors
Spain
Tumors
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Summary:Nitric oxide (NO) plays a central role in the physiololgy and pathology of diverse tissues. Different studies provide data suggesting that the endothelial cell nitric oxide synthase (NOS3) expression in peritumoral microvessels might be a prognostic indicator in breast cancer patients. However, the putative contribution of common NOS3 germline variants to breast cancer risk remained unknown. A recent work comprising 269 breast cancer patients and 244 controls suggested that NOS3 Glu298Asp polymorphism is associated to breast cancer risk (OR=1.9). We performed an independent analysis of these results in 440 unrelated patients and 321 controls from Spanish population. Although our study was 90% powered to detect ORs >/=1.55, did not find any significant difference in the Glu298Asp allele distribution between cases and controls (P > 0.42). These putative reasons for this result are discussed.
ISSN:0167-6806
1573-7217