Self-Assembly of Fibers and Fibrils

Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein‐folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-11, Vol.45 (44), p.7324-7328
Main Authors: Binder, Wolfgang H., Smrzka, Oskar W.
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer's disease
Amyloid - metabolism
fibrous proteins
gelators
Humans
Macromolecular Substances - chemistry
Molecular Structure
peptides
Prions - metabolism
self-assembly
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Summary:Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein‐folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme). These studies can serve as a starting point for the development of new therapeutic strategies.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200602001