Tick Vaccines and the Transmission of Tick-Borne Pathogens

Ticks transmit pathogens that cause diseases which greatly impact both human and animal health. Vaccines developed against Boophilus spp. using Bm86 and Bm95 tick gut antigens demonstrated the feasibility of using vaccines for control of tick infestations. These vaccines also reduced transmission of...

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Bibliographic Details
Published in:Veterinary research communications 2007-08, Vol.31 (S1), p.85-90
Main Authors: de la Fuente, J, Kocan, K. M, Blouin, E. F
Format: Article
Language:English
Subjects:
Animals
disease control
disease vectors
host-pathogen relationships
Koch's postulates
literature reviews
recombinant vaccines
tick infestations
Tick Infestations - prevention & control
Tick-Borne Diseases - prevention & control
Tick-Borne Diseases - transmission
tick-borne encephalitis
ticks
Ticks - microbiology
vaccination
vaccine development
Vaccines - immunology
vector competence
zoonoses
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Summary:Ticks transmit pathogens that cause diseases which greatly impact both human and animal health. Vaccines developed against Boophilus spp. using Bm86 and Bm95 tick gut antigens demonstrated the feasibility of using vaccines for control of tick infestations. These vaccines also reduced transmission of tick-borne pathogens by decreasing exposure of susceptible hosts to ticks. The recently discovered tick antigens, 64P putative cement protein and subolesin involved in the regulation of tick feeding and reproduction, were also shown to reduce tick infestations. These antigens, together with the TROSPA receptor for Burrelia burgdorferi OspA were effective against tick-borne pathogens by reducing the infection levels in ticks and/or the transmission of the pathogen. Development of a vaccine targeted at both the tick vector and pathogen would contribute greatly to the control of tick infestations and the transmission of tick-borne diseases. These results have demonstrated that tick vaccines can be developed for control tick infestations and show promise for the prevention of the transmission of tick-borne pathogens.
ISSN:0165-7380
1573-7446
DOI:10.1007/s11259-007-0069-5