Recent H5N1 avian Influenza A virus increases rapidly in virulence to mice after a single passage in mice

To evaluate the potential pathogenicity to mammals of the recent H5N1 avian Influenza A virus, viruses recovered from dead mice infected with A/chicken/Yamaguchi/7/2004 isolated in Japan were examined. All recovered viruses from the brains of dead mice infected with this strain (without any prior ad...

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Bibliographic Details
Published in:Journal of general virology 2006-12, Vol.87 (12), p.3655-3659
Main Authors: Mase, M, Tanimura, N, Imada, T, Okamatsu, M, Tsukamoto, K, Yamaguchi, S
Format: Article
Language:English
Subjects:
Adaptation, Biological
Amino Acid Substitution - genetics
Animals
Biological and medical sciences
Brain - virology
Chickens - virology
disease transmission
Fundamental and applied biological sciences. Psychology
Glutamic Acid - genetics
Histocytochemistry
Immunohistochemistry
Influenza A virus
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - growth & development
Influenza A Virus, H5N1 Subtype - isolation & purification
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - virology
Lysine - genetics
Mice
Microbiology
Miscellaneous
Mutation, Missense
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - virology
RNA, Viral - genetics
Viral Proteins - genetics
Virology
Virulence
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Summary:To evaluate the potential pathogenicity to mammals of the recent H5N1 avian Influenza A virus, viruses recovered from dead mice infected with A/chicken/Yamaguchi/7/2004 isolated in Japan were examined. All recovered viruses from the brains of dead mice infected with this strain (without any prior adaptation to mice) had substituted the amino acid at position 627 of the PB2 protein from glutamic acid to lysine. Their mouse lethality had increased by approximately 5 x 10(4) times over that of the original virus. Histopathological analysis reinforced the finding that these variants caused more rapid and severe damage to mice than the original virus. This revealed that it might be useful to characterize the recovered virus to assess its potential pathogenicity to mammals.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.81843-0