Characteristics of Blood Pressure in Pheochromocytoma

:  Pheochromocytomas are catecholamine‐producing tumors arising from chromaffin cells. One of the most typical symptoms of the catecholamine‐excess state is hypertension either in the sustained or paroxysmal form, and its severity does not depend on the level of circulating catecholamines. On the ot...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2006-08, Vol.1073 (1), p.86-93
Main Authors: ZELINKA, TOMÁŠ, PACAK, KAREL, WIDIMSKÝ Jr, JIŘÍ
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - physiopathology
Blood Pressure
Blood Pressure Monitoring, Ambulatory
blood pressure variability
circadian blood pressure rhythm
Humans
pheochromocytoma
Pheochromocytoma - physiopathology
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Summary::  Pheochromocytomas are catecholamine‐producing tumors arising from chromaffin cells. One of the most typical symptoms of the catecholamine‐excess state is hypertension either in the sustained or paroxysmal form, and its severity does not depend on the level of circulating catecholamines. On the other hand, hypertension in pheochromocytoma is very often characterized by the amelioration or even inversion of the circadian blood pressure rhythm. In some subjects, high circulating levels of catecholamines lead to the enhanced blood pressure variability. One possible explanation for such blood pressure variability is the desensitization of the catecholamine receptors due to high levels of circulating catecholamines.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1353.009