A proposed role for all- trans retinal in regulation of rhodopsin regeneration in human rods

In order to account for the multi-phasic dynamics of photopigment regeneration in human rods, we developed a new model of the retinoid cycle. We first examined the relative roles of the classical and channeling mechanisms of metarhodopsin decay in establishing these dynamics. We showed that neither...

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Bibliographic Details
Published in:Vision research (Oxford) 2006-12, Vol.46 (27), p.4449-4463
Main Authors: Navid, A., Nicholas, S.C., Hamer, R.D.
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Biological and medical sciences
Computational modeling
End-product regulation
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Humans
Models, Biological
Protein Structure, Quaternary
Retinal Rod Photoreceptor Cells - metabolism
Retinoid cycle
Rhodopsin
Rhodopsin - metabolism
Rhodopsin regeneration
Vertebrates: nervous system and sense organs
Vision, Ocular - physiology
Vitamin A - physiology
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Summary:In order to account for the multi-phasic dynamics of photopigment regeneration in human rods, we developed a new model of the retinoid cycle. We first examined the relative roles of the classical and channeling mechanisms of metarhodopsin decay in establishing these dynamics. We showed that neither of these mechanisms alone, nor a linear combination of the two, can adequately account for the dynamics of rhodopsin regeneration at all bleach levels. Our new model adds novel inhibitory interactions in the cycle of regeneration of rhodopsin that are consistent with the 3D structure of rhodopsin. Our analyses show that the dynamics of human rod photopigment regeneration can be accounted for by end-product regulation of the channeling mechanism where all- trans retinal ( tral) inhibits the binding of 11- cis retinal to the opsin. tral complex.
ISSN:0042-6989
1878-5646
DOI:10.1016/j.visres.2006.07.035