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Protein expression and mutational analysis of epidermal growth factor receptor in renal angiomyolipomas
Renal angiomyolipoma (AML) is a benign but progressive tumor that occasionally requires non‐surgical therapy and there appears to be a possibility that epidermal growth factor (EGF) is associated with pathogenesis of renal AML. The response to gefitinib, anti‐epidermal growth factor receptor (EGFR)...
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Published in: | Pathology international 2007-09, Vol.57 (9), p.584-588 |
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description | Renal angiomyolipoma (AML) is a benign but progressive tumor that occasionally requires non‐surgical therapy and there appears to be a possibility that epidermal growth factor (EGF) is associated with pathogenesis of renal AML. The response to gefitinib, anti‐epidermal growth factor receptor (EGFR) agent and a prime example of target therapy, reportedly has been correlated with the presence of mutations within the tyrosine kinase (TK) domain of EGFR or the expression of its truncated form, EGFR variant III. Therefore the purpose of the present paper was to investigate EGFR protein expression and gene mutations in exons 18, 19 and 21 in 40 renal AML. No EGFR gene mutations of TK domain were detected in any of the 40 cases studied and strong immunostaining was found in 5% of the renal AML cases. The present findings indicate that in renal AML, anti‐EGFR treatment may not be promising but that there is a possibility that EGFR is associated with renal AML pathogenesis. |
doi_str_mv | 10.1111/j.1440-1827.2007.02142.x |
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The response to gefitinib, anti‐epidermal growth factor receptor (EGFR) agent and a prime example of target therapy, reportedly has been correlated with the presence of mutations within the tyrosine kinase (TK) domain of EGFR or the expression of its truncated form, EGFR variant III. Therefore the purpose of the present paper was to investigate EGFR protein expression and gene mutations in exons 18, 19 and 21 in 40 renal AML. No EGFR gene mutations of TK domain were detected in any of the 40 cases studied and strong immunostaining was found in 5% of the renal AML cases. 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The response to gefitinib, anti‐epidermal growth factor receptor (EGFR) agent and a prime example of target therapy, reportedly has been correlated with the presence of mutations within the tyrosine kinase (TK) domain of EGFR or the expression of its truncated form, EGFR variant III. Therefore the purpose of the present paper was to investigate EGFR protein expression and gene mutations in exons 18, 19 and 21 in 40 renal AML. No EGFR gene mutations of TK domain were detected in any of the 40 cases studied and strong immunostaining was found in 5% of the renal AML cases. The present findings indicate that in renal AML, anti‐EGFR treatment may not be promising but that there is a possibility that EGFR is associated with renal AML pathogenesis.</description><subject>Adult</subject><subject>Aged</subject><subject>angiomyolipoma</subject><subject>Angiomyolipoma - genetics</subject><subject>Angiomyolipoma - metabolism</subject><subject>Angiomyolipoma - pathology</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Neoplasm - analysis</subject><subject>epidermal growth factor receptor</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>kidney</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Polymerase Chain Reaction</subject><subject>pyrosequencing</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u3CAUhVHVqvlpX6Hyqjs7wLWNWXRRRU0mVTSdSom6RAy-TJnagwseZebtg-NRui0LOBfOOUgfIRmjBUvraluwsqQ5a7goOKWioJyVvDi8IeevD2-TBk7zqqzhjFzEuKWUCajpe3LGRN1UkstzslkFP6LbZXgYAsbo_C7Tuzbr96Me06C7NOruGF3MvM1wcC2GPt1ugn8af2dWm9GHLKDBYRKpKeCc2jjfH33nBt_r-IG8s7qL-PF0XpLHm28P14v8_sft3fXX-9xUouS5rWwrDEiJ6ybt60ZSQC05tICcGhCMg0bDGmmBc6HBMjDUrqG2ppWlhEvyee4dgv-7xziq3kWDXad36PdR1U0CxBuejM1sNMHHGNCqIbheh6NiVE2Q1VZNLNXEUk2Q1QtkdUjRT6c_9use23_BE9Vk-DIbnlyHx_8uVqu75aRSPp_zLo54eM3r8EfVAkSlfi1vlfwuVgtY_FRLeAavApwu</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Lim, So Dug</creator><creator>Kim, Wanseop</creator><creator>Ahn, Geunghwan</creator><creator>Kwon, Ghee Young</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Protein expression and mutational analysis of epidermal growth factor receptor in renal angiomyolipomas</title><author>Lim, So Dug ; Kim, Wanseop ; Ahn, Geunghwan ; Kwon, Ghee Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5742-f5fd7c399eb8399b8903ea923d3e20c37123aec189f3227a3f13c0fb36fcd9493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>angiomyolipoma</topic><topic>Angiomyolipoma - genetics</topic><topic>Angiomyolipoma - metabolism</topic><topic>Angiomyolipoma - pathology</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Neoplasm - analysis</topic><topic>epidermal growth factor receptor</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>kidney</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Polymerase Chain Reaction</topic><topic>pyrosequencing</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, So Dug</creatorcontrib><creatorcontrib>Kim, Wanseop</creatorcontrib><creatorcontrib>Ahn, Geunghwan</creatorcontrib><creatorcontrib>Kwon, Ghee Young</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, So Dug</au><au>Kim, Wanseop</au><au>Ahn, Geunghwan</au><au>Kwon, Ghee Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein expression and mutational analysis of epidermal growth factor receptor in renal angiomyolipomas</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2007-09</date><risdate>2007</risdate><volume>57</volume><issue>9</issue><spage>584</spage><epage>588</epage><pages>584-588</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Renal angiomyolipoma (AML) is a benign but progressive tumor that occasionally requires non‐surgical therapy and there appears to be a possibility that epidermal growth factor (EGF) is associated with pathogenesis of renal AML. The response to gefitinib, anti‐epidermal growth factor receptor (EGFR) agent and a prime example of target therapy, reportedly has been correlated with the presence of mutations within the tyrosine kinase (TK) domain of EGFR or the expression of its truncated form, EGFR variant III. Therefore the purpose of the present paper was to investigate EGFR protein expression and gene mutations in exons 18, 19 and 21 in 40 renal AML. No EGFR gene mutations of TK domain were detected in any of the 40 cases studied and strong immunostaining was found in 5% of the renal AML cases. The present findings indicate that in renal AML, anti‐EGFR treatment may not be promising but that there is a possibility that EGFR is associated with renal AML pathogenesis.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>17685929</pmid><doi>10.1111/j.1440-1827.2007.02142.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged angiomyolipoma Angiomyolipoma - genetics Angiomyolipoma - metabolism Angiomyolipoma - pathology DNA Mutational Analysis DNA, Neoplasm - analysis epidermal growth factor receptor Female Fluorescent Antibody Technique, Indirect Humans immunohistochemistry kidney Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Male Middle Aged Mutation Polymerase Chain Reaction pyrosequencing Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism |
title | Protein expression and mutational analysis of epidermal growth factor receptor in renal angiomyolipomas |
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