Renal Cell Cancer and Body Size at Different Ages: An Italian Multicenter Case-Control Study

An increased risk of renal cell cancer (RCC) has been reported in overweight persons. The authors aimed to clarify which anthropometric measures are associated with risk of RCC and whether risk may vary according to selected variables. Between 1992 and 2004, they carried out an Italian multicenter c...

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Bibliographic Details
Published in:American journal of epidemiology 2007-09, Vol.166 (5), p.582-591
Main Authors: Dal Maso, Luigino, Zucchetto, Antonella, Tavani, Alessandra, Montella, Maurizio, Ramazzotti, Valerio, Talamini, Renato, Canzonieri, Vincenzo, Garbeglio, Antonio, Negri, Eva, Tonini, Annamaria, La Vecchia, Carlo, Franceschi, Silvia
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Analysis. Health state
Biological and medical sciences
Body fat
Body Mass Index
Body Size
Cancer
carcinoma
Carcinoma, Renal Cell - epidemiology
Case-Control Studies
Epidemiology
Female
General aspects
Humans
Incidence
Italy - epidemiology
Kidney diseases
Kidney Neoplasms - epidemiology
Kidneys
Logistic Models
Male
Medical sciences
Middle Aged
Miscellaneous
Nephrology. Urinary tract diseases
Obesity
Public health. Hygiene
Public health. Hygiene-occupational medicine
renal cell
Risk Factors
Surveys and Questionnaires
Tumors of the urinary system
waist-hip ratio
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Summary:An increased risk of renal cell cancer (RCC) has been reported in overweight persons. The authors aimed to clarify which anthropometric measures are associated with risk of RCC and whether risk may vary according to selected variables. Between 1992 and 2004, they carried out an Italian multicenter case-control study including 767 (494 men, 273 women) incident cases of RCC and 1,534 hospital controls, frequency-matched to cases. To estimate odds ratios and 95% confidence intervals, they used conditional logistic regression matched on study center, sex, and age and adjusted for period of interview, years of education, smoking habits, and family history of kidney cancer. Using body-size measurements taken 1 year prior to diagnosis/interview, the authors found an odds ratio of 1.3 (95% confidence interval (CI): 1.0, 1.7) among obese persons (body mass index (BMI; weight (kg)/height (m)2) ≥30) versus normal-weight persons (BMI
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwm108