Human Granulocytic Anaplasmosis During Pregnancy: Case Series and Literature Review

We describe the clinical and laboratory manifestations and pregnancy outcomes of 6 women who received a diagnosis of human granulocytic ehrlichiosis during pregnancy. Human granulocytic ehrlichiosis did not seem to present in a fulminant fashion, and all treated patients had excellent responses to r...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-09, Vol.45 (5), p.589-593
Main Authors: Dhand, Abhay, Nadelman, Robert B., Aguero-Rosenfeld, Maria, Haddad, Fadi A., Stokes, Daniela P., Horowitz, Harold W.
Format: Article
Language:English
Subjects:
Adult
Anaplasma phagocytophilum - drug effects
Anaplasma phagocytophilum - pathogenicity
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biological and medical sciences
Blood
Brief Reports
Clinical outcomes
Disease transmission
Doxycycline - therapeutic use
Drug therapy
Ehrlichiosis
Ehrlichiosis - complications
Ehrlichiosis - drug therapy
Ehrlichiosis - transmission
Female
Fever
Follow-Up Studies
Humans
Infant, Newborn
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Medical sciences
New York
Newborns
Patients
Polymerase chain reaction
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Outcome
Rifampin - therapeutic use
Thrombocytopenia
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Summary:We describe the clinical and laboratory manifestations and pregnancy outcomes of 6 women who received a diagnosis of human granulocytic ehrlichiosis during pregnancy. Human granulocytic ehrlichiosis did not seem to present in a fulminant fashion, and all treated patients had excellent responses to rifampin or doxycycline therapy. Perinatal transmission was documented in 1 neonate, who responded well to treatment. There do not appear to be any long-term adverse sequelae in children born from these pregnancies (mean follow-up duration, 21 months).
ISSN:1058-4838
1537-6591
DOI:10.1086/520659