Rgs 2 gene polymorphisms as modulators of anxiety in humans?

Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of...

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Bibliographic Details
Published in:Journal of Neural Transmission 2006-12, Vol.113 (12), p.1921-1925
Main Authors: Leygraf, A, Hohoff, C, Freitag, C, Willis-Owen, S A G, Krakowitzky, P, Fritze, J, Franke, P, Bandelow, B, Fimmers, R, Flint, J, Deckert, J
Format: Article
Language:English
Subjects:
Agoraphobia - complications
Agoraphobia - genetics
Agoraphobia - psychology
Anxiety
Anxiety - genetics
Anxiety - psychology
Case-Control Studies
Chromosomes, Human, Pair 1 - genetics
DNA Primers
Humans
Linkage Disequilibrium
Odds Ratio
Panic Disorder - genetics
Panic Disorder - psychology
Polymorphism, Single Nucleotide - genetics
Psychiatric Status Rating Scales
Reverse Transcriptase Polymerase Chain Reaction
RGS Proteins - genetics
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Summary:Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-006-0484-8