Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei

Abstract A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainst...

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Bibliographic Details
Published in:Journal of the neurological sciences 2007-09, Vol.260 (1), p.271-274
Main Authors: Nishio, Yoshiyuki, Ishii, Kazunari, Kazui, Hiroaki, Hosokai, Yoshiyuki, Mori, Etsuro
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Brain Mapping
Brain Stem - diagnostic imaging
Brain Stem - metabolism
Brain Stem - physiopathology
Brain Stem Infarctions - complications
Brain Stem Infarctions - physiopathology
Cerebrovascular Circulation - physiology
Dementia - diagnostic imaging
Dementia - etiology
Dementia - physiopathology
Dopamine - metabolism
Female
Frontal Lobe - diagnostic imaging
Frontal Lobe - metabolism
Frontal Lobe - physiopathology
Frontal-lobe syndorome
Frontal-subcortical circuits
Hallucinations
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Magnetic Resonance Imaging
Malformations of the nervous system
Medical sciences
Mesocorticolimbic dopaminergic system
Nervous system (semeiology, syndromes)
Neural Pathways - diagnostic imaging
Neural Pathways - metabolism
Neural Pathways - physiopathology
Neurology
Pons - diagnostic imaging
Pons - metabolism
Pons - physiopathology
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - etiology
Psychotic Disorders - physiopathology
Rostral brainstem
Tegmentum Mesencephali - diagnostic imaging
Tegmentum Mesencephali - metabolism
Tegmentum Mesencephali - physiopathology
Tomography, Emission-Computed, Single-Photon
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Summary:Abstract A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstem dopaminergic nuclei and hypoperfusion in the frontal-subcortical circuit components. We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2007.04.021