Surface Grafting of PEO-Based Star-Shaped Molecules for Bioanalytical and Biomedical Applications

This article reviews surface grafting of star‐shaped PEO. The use of star‐shaped polymers is compared to linear PEO chains regarding the layer preparation and the ability of the resulting surfaces to resist protein adsorption. We then focus on the use of end‐functionalized, star‐shaped, PEO‐based pr...

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Bibliographic Details
Published in:Macromolecular bioscience 2007-08, Vol.7 (8), p.1010-1023
Main Authors: Gasteier, Peter, Reska, Anna, Schulte, Petra, Salber, Jochen, Offenhäusser, Andreas, Moeller, Martin, Groll, Jürgen
Format: Article
Language:English
Subjects:
Animals
biocompatibility
Biocompatible Materials - chemistry
Cell Adhesion - drug effects
Cell Proliferation - drug effects
functionality
Humans
hydrogel coating
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - drug effects
Molecular Conformation
molecular recognition
Molecular Weight
Nanotechnology
Neurons - cytology
Neurons - drug effects
PEO star polymers
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Proteins
Surface Properties
Tissue Engineering - instrumentation
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Summary:This article reviews surface grafting of star‐shaped PEO. The use of star‐shaped polymers is compared to linear PEO chains regarding the layer preparation and the ability of the resulting surfaces to resist protein adsorption. We then focus on the use of end‐functionalized, star‐shaped, PEO‐based prepolymers that are able to form covalent crosslinks and functional polymer networks on the substrate. Examples are given for specific protein adsorption as well as for cell adhesion on such layers by covalent embedding of biofunctional molecules. The possibility of coating biomedically relevant polymer substrates in three‐dimensional geometries is discussed and examples are shown for poly(ethylene terephthalate) monofilament constructs.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.200700064