Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease

This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson&...

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Bibliographic Details
Published in:Brain research bulletin 2006-12, Vol.71 (1), p.149-154
Main Authors: Priori, A., Ardolino, G., Marceglia, S., Mrakic-Sposta, S., Locatelli, M., Tamma, F., Rossi, L., Foffani, G.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Adult
Aged
Basal ganglia
Basal Ganglia - anatomy & histology
Basal Ganglia - physiopathology
Biological Clocks - physiology
DBS
Deep Brain Stimulation - methods
Electrodes - standards
Female
Human
Humans
LFPs
Local field potentials
Male
Middle Aged
Nerve Net - anatomy & histology
Nerve Net - physiopathology
Neural Pathways - anatomy & histology
Neural Pathways - physiopathology
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
STN
Subthalamic nucleus
Subthalamic Nucleus - anatomy & histology
Subthalamic Nucleus - physiology
Treatment Outcome
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Summary:This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1–1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change = 0.93 ± 0.62; Wilcoxon: p = 0.0002, n = 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain–electrode interface.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2006.08.015