Occurence of Stromal Myofibroblasts in the Invasive Ductal Breast Cancer Tissue is an Unfavourable Prognostic Factor

Background: Numerous experimental studies have described the capacity of myofibroblasts to stimulate mammary cancer cells in a paracrine manner. Until now, the prognostic significance of myofibroblasts present in breast cancer has not been examined. Patients and Methods: In paraffin sections, origin...

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Published in:Anticancer research 2007-07, Vol.27 (4C), p.2917-2924
Main Authors: SUROWIAK, Pawel, MURAWA, Dawid, LAGE, Hermann, MATERNA, Verena, MACIEJCZYK, Adam, PUDELKO, Marek, CIESLA, Slawomir, BREBOROWICZ, Jan, MURAWA, Pawel, ZABEL, Maciej, DIETEL, Manfred
Format: Article
Language:English
Subjects:
Actins - biosynthesis
Biological and medical sciences
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Female
Fibroblast Growth Factor 2 - biosynthesis
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Ki-67 Antigen - biosynthesis
Mammary gland diseases
Medical sciences
Middle Aged
Myoblasts - metabolism
Myoblasts - pathology
Retrospective Studies
Stromal Cells - metabolism
Stromal Cells - pathology
Tumors
Urokinase-Type Plasminogen Activator - biosynthesis
Vascular Endothelial Growth Factor A - biosynthesis
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Summary:Background: Numerous experimental studies have described the capacity of myofibroblasts to stimulate mammary cancer cells in a paracrine manner. Until now, the prognostic significance of myofibroblasts present in breast cancer has not been examined. Patients and Methods: In paraffin sections, originating from 45 patients with primary invasive breast cancer, immunohistochemical reactions were performed using antibodies directed against smooth muscle actin, Ki-67, VEGF, bFGF and UPA. Results: The cases with higher content of myofibroblasts in the tumour tissue manifested higher grade, more pronounced expression of Ki-67, VEGF and bFGF and shorter overall survival and relapse-free survival. Conclusion: The present study for the first time documents the unfavourable prognostic significance of myofibroblasts in tissues of invasive ductal mammary carcinomas.
ISSN:0250-7005
1791-7530