Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabetes

Abstract Pinitol (3- O -methyl- d -chiro-inositol) was identified in putative insulin mediator fractions that have hypoglycemic activity, and appears to mimic the act effects of insulin by acting downstream in the insulin signaling pathway. We evaluated the effect of pinitol therapy in type 2 diabet...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes research and clinical practice 2007-09, Vol.77 (3), p.S247-S251
Main Authors: Kim, Mi Jin, Yoo, Kwang Ha, Kim, Ji Hoon, Seo, Young Tak, Ha, Byung Wook, Kho, Jang Hyun, Shin, Young Goo, Chung, Choon Hee
Format: Article
Language:English
Subjects:
Adipocytokine
Adiponectin - blood
Aged
Blood Glucose - drug effects
Blood Glucose - metabolism
C-Reactive Protein - metabolism
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Drug Therapy, Combination
Endocrinology & Metabolism
Fatty Acids, Nonesterified - blood
Female
Glycated Hemoglobin A - metabolism
Humans
Hypoglycemic Agents - therapeutic use
Inositol - analogs & derivatives
Inositol - pharmacology
Leptin - blood
Male
Middle Aged
Pinitol
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Pinitol (3- O -methyl- d -chiro-inositol) was identified in putative insulin mediator fractions that have hypoglycemic activity, and appears to mimic the act effects of insulin by acting downstream in the insulin signaling pathway. We evaluated the effect of pinitol therapy in type 2 diabetic patients who were poorly controlled with hypoglycemic drugs, such as sulfonylurea, metformin and/or insulin. Twenty type 2 diabetic patients were enrolled in our study. Fasting glucose, fasting c-peptide, total cholesterol, triglyceride, and HDL- and LDL-cholesterol were checked before and after a 12-week pinitol treatment (20 mg kg−1 day−1 ). All subjects continued their current medications during the study. Adipocytokines, such as adiponectin, leptin, free fatty acids, and c-reactive protein (CRP) were checked before and after pinitol treatment. After pinitol treatment, fasting glucose, post-prandial glucose levels, and hemoglobin A1c were significantly decreased ( P < 0.05). Fasting serum adiponectin, leptin, free fatty acid, and CRP levels did not change after pinitol treatment. In the unresponsive group, serum c-peptide levels were higher than in the responsive group. Twelve weeks of pinitol treatment altered glucose metabolism, but not lipid profiles or adipocytokine levels, in type 2 diabetic patients. Additional research is needed to define the physiological and potential therapeutic effects of pinitol administration.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2007.01.066