Uncomplicated urinary tract infections, what about fosfomycin and nitrofurantoin in 2006?

Since 2000 to 2005 we assessed the prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated urinary tract infections (UTI). A total of 19 618 bacteria were studied, fosfomycin, fluoroquinolones, nitrofurantoin were in vitro the most potent drugs with more than 80% of sus...

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Bibliographic Details
Published in:Pathologie biologie (Paris) 2006-10, Vol.54 (8-9), p.462-466
Main Authors: Honderlick, P, Cahen, P, Gravisse, J, Vignon, D
Format: Article
Language:eng ; fre
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents, Urinary - therapeutic use
Escherichia coli - drug effects
Fosfomycin - therapeutic use
France - epidemiology
Humans
Microbial Sensitivity Tests
Nitrofurans - therapeutic use
Prevalence
Urinary Tract Infections - drug therapy
Urinary Tract Infections - epidemiology
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Summary:Since 2000 to 2005 we assessed the prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated urinary tract infections (UTI). A total of 19 618 bacteria were studied, fosfomycin, fluoroquinolones, nitrofurantoin were in vitro the most potent drugs with more than 80% of susceptibility. If we compare year 2000 to 2005 we observed a significant decrease of susceptibility for fluoroquinolones. For the same point of comparison, fosfomycin and nitrofurantoin showed a favourable evolution. Rationale and prudent use of antibiotics must now moved us to prescribe parsimoniously fluoroquinolones especially for some indications such as uncomplicated UTI though there are some others "old antibiotics" with a role may be underestimated for this specific indication.
ISSN:0369-8114
DOI:10.1016/j.patbio.2006.07.016