A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa

Abstract This study revealed that a Pseudomonas aeruginosa tonB1 mutant was unable to produce a mature biofilm and showed reduced swarming and twitching motilities compared with the parent strain. The tonB1 mutant was also found to produce significantly lower cell-free and cell-associated levels of...

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Bibliographic Details
Published in:FEMS microbiology letters 2007-09, Vol.274 (2), p.269-278
Main Authors: Abbas, Abdelhamid, Adams, Claire, Scully, Norma, Glennon, Jeremy, O'Gara, Fergal
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - biosynthesis
Bacteriology
biofilm
Biofilms
Biofilms - growth & development
Biological and medical sciences
Escherichia coli Proteins - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial
Lactones
Membrane Proteins - metabolism
Metabolism. Enzymes
Microbiology
motility
Phenotypes
Pseudomonas aeruginosa
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - physiology
Quorum sensing
Quorum Sensing - physiology
Signal Transduction - physiology
Swarming
TonB1
Twitching
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Summary:Abstract This study revealed that a Pseudomonas aeruginosa tonB1 mutant was unable to produce a mature biofilm and showed reduced swarming and twitching motilities compared with the parent strain. The tonB1 mutant was also found to produce significantly lower cell-free and cell-associated levels of the quorum sensing (QS) signal molecule 3-oxo-C12-AHL. Altered biofilm and motility phenotypes were restored to wildtype with the addition of exogenous N-acylhomoserine lactones. These functions were independent of the role of TonB1 in iron uptake. This is the first time that a link has been established between TonB1 activity and QS.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2007.00845.x