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Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction
Background/Aims Studies of the prognostic importance of QRS duration in patients with heart failure (HF) have shown conflicting results and few studies have estimated the importance after myocardial infarction (MI). Methods The Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study rando...
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| Published in: | European journal of heart failure 2007-08, Vol.9 (8), p.814-819 |
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| cites | cdi_FETCH-LOGICAL-c4925-dd83f34de6f8d3aef2af79fc0583c643e59c0a2acea650b911339649141cab3b3 |
| container_end_page | 819 |
| container_issue | 8 |
| container_start_page | 814 |
| container_title | European journal of heart failure |
| container_volume | 9 |
| creator | Fosbøl, Emil Loldrup Seibæk, Marie Brendorp, Bente Møller, Daniél Vega Ersbøll, Mads Torp-Pedersen, Christian Køber, Lars |
| description | Background/Aims
Studies of the prognostic importance of QRS duration in patients with heart failure (HF) have shown conflicting results and few studies have estimated the importance after myocardial infarction (MI).
Methods
The Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study randomised 3028 patients to dofetilide (class III antiarrhythmic) or placebo. The study consisted of two almost identical trials conducted simultaneously. One trial included 1518 patients with chronic HF and the other trial 1510 patients with a recent MI. All patients had left ventricular dysfunction. Dofetilide did not influence mortality in either trial. QRS duration was systematically measured at randomisation and was available in 2972 patients.
Results
Over a 10 year observation period 1037 (70%) patients in the MI study and 1324 (87%) in the HF study died. In the MI study, risk of death increased 6% for each 10 ms increase in QRS duration (HR=1.06/10 ms increase in QRS (CI=1.04-1.09), p |
| doi_str_mv | 10.1016/j.ejheart.2007.04.005 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68162439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1016/j.ejheart.2007.04.005</oup_id><sourcerecordid>68162439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4925-dd83f34de6f8d3aef2af79fc0583c643e59c0a2acea650b911339649141cab3b3</originalsourceid><addsrcrecordid>eNqNkctuFDEQRVsIRELgE0BesevGr354CSEPogAiAcHOqrHLxENPe7DdhPkLPjk90yMQu6zKi3vurfItiueMVoyy5tWywuUNQswVp7StqKworR8Uh6xrVUk7KR9Ob9F1peokPyiepLSklLWU8sfFAWvrljPZHhZ_3nrnMOKQPfRkHcP3IaTsDfGrdYgZBoMkOPLp6prYMUL2YSB-ILtk4sD3Y0QCgyVgxoxktQkGot16-cFBNDsAUgrGQ0ZLbn2-IT26TH5NmdGbsYdI7Ca5cdiJnxaPHPQJn-3nUfHl9OTz8Xl5-fHs3fHry9JIxevS2k44IS02rrMC0HFwrXKG1p0wjRRYK0OBg0FoarpQjAmhGqmYZAYWYiGOipez73TzzxFT1iufDPY9DBjGpJuONVwKNQnrWWhiSCmi0-voVxA3mlG9rUIv9b4Kva1CU6mnKibuxT5gXKzQ_qP2fz8J3syCW9_j5n6u-uTi_PT_FDqbhHF978XKGfEp4--_EMQfumlFW-uvH860uH7_jV9xpam4A4thvt8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68162439</pqid></control><display><type>article</type><title>Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Fosbøl, Emil Loldrup ; Seibæk, Marie ; Brendorp, Bente ; Møller, Daniél Vega ; Ersbøll, Mads ; Torp-Pedersen, Christian ; Køber, Lars</creator><creatorcontrib>Fosbøl, Emil Loldrup ; Seibæk, Marie ; Brendorp, Bente ; Møller, Daniél Vega ; Ersbøll, Mads ; Torp-Pedersen, Christian ; Køber, Lars ; Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group ; for the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</creatorcontrib><description>Background/Aims
Studies of the prognostic importance of QRS duration in patients with heart failure (HF) have shown conflicting results and few studies have estimated the importance after myocardial infarction (MI).
Methods
The Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study randomised 3028 patients to dofetilide (class III antiarrhythmic) or placebo. The study consisted of two almost identical trials conducted simultaneously. One trial included 1518 patients with chronic HF and the other trial 1510 patients with a recent MI. All patients had left ventricular dysfunction. Dofetilide did not influence mortality in either trial. QRS duration was systematically measured at randomisation and was available in 2972 patients.
Results
Over a 10 year observation period 1037 (70%) patients in the MI study and 1324 (87%) in the HF study died. In the MI study, risk of death increased 6% for each 10 ms increase in QRS duration (HR=1.06/10 ms increase in QRS (CI=1.04-1.09), p<0.0001) whereas QRS duration had no influence in the HF study after multivariable adjustment. The difference between HF and MI was significant (p<0.0004 for interaction).
Conclusion
QRS duration predicts death in patients with left ventricular dysfunction who have suffered MI. In patients with HF QRS duration is not predictive of mortality.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1016/j.ejheart.2007.04.005</identifier><identifier>PMID: 17572147</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>acute myocardial infarction ; Aged ; Aged, 80 and over ; Female ; Heart Conduction System - physiopathology ; heart failure ; Humans ; left ventricular dysfunction ; Male ; Middle Aged ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Prognosis ; Proportional Hazards Models ; QRS duration ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>European journal of heart failure, 2007-08, Vol.9 (8), p.814-819</ispartof><rights>2007 European Society of Cardiology 2007</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © 2007 the Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4925-dd83f34de6f8d3aef2af79fc0583c643e59c0a2acea650b911339649141cab3b3</citedby><cites>FETCH-LOGICAL-c4925-dd83f34de6f8d3aef2af79fc0583c643e59c0a2acea650b911339649141cab3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17572147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fosbøl, Emil Loldrup</creatorcontrib><creatorcontrib>Seibæk, Marie</creatorcontrib><creatorcontrib>Brendorp, Bente</creatorcontrib><creatorcontrib>Møller, Daniél Vega</creatorcontrib><creatorcontrib>Ersbøll, Mads</creatorcontrib><creatorcontrib>Torp-Pedersen, Christian</creatorcontrib><creatorcontrib>Køber, Lars</creatorcontrib><creatorcontrib>Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</creatorcontrib><creatorcontrib>for the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</creatorcontrib><title>Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction</title><title>European journal of heart failure</title><addtitle>European Journal of Heart Failure</addtitle><description>Background/Aims
Studies of the prognostic importance of QRS duration in patients with heart failure (HF) have shown conflicting results and few studies have estimated the importance after myocardial infarction (MI).
Methods
The Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study randomised 3028 patients to dofetilide (class III antiarrhythmic) or placebo. The study consisted of two almost identical trials conducted simultaneously. One trial included 1518 patients with chronic HF and the other trial 1510 patients with a recent MI. All patients had left ventricular dysfunction. Dofetilide did not influence mortality in either trial. QRS duration was systematically measured at randomisation and was available in 2972 patients.
Results
Over a 10 year observation period 1037 (70%) patients in the MI study and 1324 (87%) in the HF study died. In the MI study, risk of death increased 6% for each 10 ms increase in QRS duration (HR=1.06/10 ms increase in QRS (CI=1.04-1.09), p<0.0001) whereas QRS duration had no influence in the HF study after multivariable adjustment. The difference between HF and MI was significant (p<0.0004 for interaction).
Conclusion
QRS duration predicts death in patients with left ventricular dysfunction who have suffered MI. In patients with HF QRS duration is not predictive of mortality.</description><subject>acute myocardial infarction</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Heart Conduction System - physiopathology</subject><subject>heart failure</subject><subject>Humans</subject><subject>left ventricular dysfunction</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>QRS duration</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkctuFDEQRVsIRELgE0BesevGr354CSEPogAiAcHOqrHLxENPe7DdhPkLPjk90yMQu6zKi3vurfItiueMVoyy5tWywuUNQswVp7StqKworR8Uh6xrVUk7KR9Ob9F1peokPyiepLSklLWU8sfFAWvrljPZHhZ_3nrnMOKQPfRkHcP3IaTsDfGrdYgZBoMkOPLp6prYMUL2YSB-ILtk4sD3Y0QCgyVgxoxktQkGot16-cFBNDsAUgrGQ0ZLbn2-IT26TH5NmdGbsYdI7Ca5cdiJnxaPHPQJn-3nUfHl9OTz8Xl5-fHs3fHry9JIxevS2k44IS02rrMC0HFwrXKG1p0wjRRYK0OBg0FoarpQjAmhGqmYZAYWYiGOipez73TzzxFT1iufDPY9DBjGpJuONVwKNQnrWWhiSCmi0-voVxA3mlG9rUIv9b4Kva1CU6mnKibuxT5gXKzQ_qP2fz8J3syCW9_j5n6u-uTi_PT_FDqbhHF978XKGfEp4--_EMQfumlFW-uvH860uH7_jV9xpam4A4thvt8</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Fosbøl, Emil Loldrup</creator><creator>Seibæk, Marie</creator><creator>Brendorp, Bente</creator><creator>Møller, Daniél Vega</creator><creator>Ersbøll, Mads</creator><creator>Torp-Pedersen, Christian</creator><creator>Køber, Lars</creator><general>Blackwell Publishing Ltd</general><general>Elsevier</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction</title><author>Fosbøl, Emil Loldrup ; Seibæk, Marie ; Brendorp, Bente ; Møller, Daniél Vega ; Ersbøll, Mads ; Torp-Pedersen, Christian ; Køber, Lars</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4925-dd83f34de6f8d3aef2af79fc0583c643e59c0a2acea650b911339649141cab3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>acute myocardial infarction</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Heart Conduction System - physiopathology</topic><topic>heart failure</topic><topic>Humans</topic><topic>left ventricular dysfunction</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>QRS duration</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fosbøl, Emil Loldrup</creatorcontrib><creatorcontrib>Seibæk, Marie</creatorcontrib><creatorcontrib>Brendorp, Bente</creatorcontrib><creatorcontrib>Møller, Daniél Vega</creatorcontrib><creatorcontrib>Ersbøll, Mads</creatorcontrib><creatorcontrib>Torp-Pedersen, Christian</creatorcontrib><creatorcontrib>Køber, Lars</creatorcontrib><creatorcontrib>Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</creatorcontrib><creatorcontrib>for the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fosbøl, Emil Loldrup</au><au>Seibæk, Marie</au><au>Brendorp, Bente</au><au>Møller, Daniél Vega</au><au>Ersbøll, Mads</au><au>Torp-Pedersen, Christian</au><au>Køber, Lars</au><aucorp>Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</aucorp><aucorp>for the Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction</atitle><jtitle>European journal of heart failure</jtitle><addtitle>European Journal of Heart Failure</addtitle><date>2007-08</date><risdate>2007</risdate><volume>9</volume><issue>8</issue><spage>814</spage><epage>819</epage><pages>814-819</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Background/Aims
Studies of the prognostic importance of QRS duration in patients with heart failure (HF) have shown conflicting results and few studies have estimated the importance after myocardial infarction (MI).
Methods
The Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) study randomised 3028 patients to dofetilide (class III antiarrhythmic) or placebo. The study consisted of two almost identical trials conducted simultaneously. One trial included 1518 patients with chronic HF and the other trial 1510 patients with a recent MI. All patients had left ventricular dysfunction. Dofetilide did not influence mortality in either trial. QRS duration was systematically measured at randomisation and was available in 2972 patients.
Results
Over a 10 year observation period 1037 (70%) patients in the MI study and 1324 (87%) in the HF study died. In the MI study, risk of death increased 6% for each 10 ms increase in QRS duration (HR=1.06/10 ms increase in QRS (CI=1.04-1.09), p<0.0001) whereas QRS duration had no influence in the HF study after multivariable adjustment. The difference between HF and MI was significant (p<0.0004 for interaction).
Conclusion
QRS duration predicts death in patients with left ventricular dysfunction who have suffered MI. In patients with HF QRS duration is not predictive of mortality.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>17572147</pmid><doi>10.1016/j.ejheart.2007.04.005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1388-9842 |
| ispartof | European journal of heart failure, 2007-08, Vol.9 (8), p.814-819 |
| issn | 1388-9842 1879-0844 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | acute myocardial infarction Aged Aged, 80 and over Female Heart Conduction System - physiopathology heart failure Humans left ventricular dysfunction Male Middle Aged Myocardial Infarction - mortality Myocardial Infarction - physiopathology Prognosis Proportional Hazards Models QRS duration Ventricular Dysfunction, Left - physiopathology |
| title | Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction |
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