Decreased Expression of DARPP-32 in Oral Premalignant and Malignant Lesions

Background: DARPP-32 is a neuronal protein that plays a central role in dopaminergic neurotransmission. Although DARPP-32 may contribute to the pathogenesis of several human malignancies, its expression has never been investigated in oral premalignant and malignant lesions. Materials and Methods: DA...

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Published in:Anticancer research 2007-07, Vol.27 (4B), p.2339-2343
Main Authors: FLÁVIO JULIANO PIMENTA, MARTINHO CAMPOLINA REBELLO HORTA, PAULA VIEIRA VIDIGAL, BRUNO REZENDE DE SOUZA, LUIZ DE MARCO, MARCO AURÉLIO ROMANO-SILVA, RICARDO SANTIAGO GOMEZ
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Dopamine and cAMP-Regulated Phosphoprotein 32 - biosynthesis
Female
Humans
Immunohistochemistry
Leukoplakia, Oral - metabolism
Male
Medical sciences
Middle Aged
Mouth Mucosa - metabolism
Mouth Neoplasms - metabolism
Otorhinolaryngology. Stomatology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background: DARPP-32 is a neuronal protein that plays a central role in dopaminergic neurotransmission. Although DARPP-32 may contribute to the pathogenesis of several human malignancies, its expression has never been investigated in oral premalignant and malignant lesions. Materials and Methods: DARPP-32 expression was examined using immunohistochemistry in 14 normal oral mucosa, 5 normal lower lip mucosa, 41 oral leukoplakia (OL), 30 oral squamous cell carcinoma (OSCC) and 20 lower lip squamous cell carcinoma (LLSCC) specimens. Differences of its expression between groups were analyzed. Results: OSCC and OL with moderate or severe dysplasia showed lower DARPP-32 expression in relation to normal oral mucosa. LLSCC showed lower DARPP-32 expression than normal lower lip mucosa and OSSC. Conclusion: The decreased expression of DARPP-32 in oral premalignant and malignant lesions suggests a tumor suppressor role for this protein in the tumorigenesis of these lesions.
ISSN:0250-7005
1791-7530