Reactions of PtII diamine anticancer complexes with trypanothione and octreotide

The products formed in reactions of the square-planar platinum(II) anticancer complexes, [Pt(en)Cl(2)] and [Pt(R,R-dach)Cl(2)] where en=ethylenediamine and dach=diaminocyclohexane, with trypanothione, a glutathione analogue found in some parasites, and octreotide, a synthetic analogue of the hormone...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2006-12, Vol.100 (12), p.1946-1954
Main Authors: Munk, Vivienne P, Fakih, Sarah, Socorro Murdoch, Piedad Del, Sadler, Peter J
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Chromatography, Liquid
Glutathione - analogs & derivatives
Glutathione - chemistry
Mass Spectrometry
Octreotide - chemistry
Platinum Compounds - chemistry
Spectrophotometry, Ultraviolet
Spermidine - analogs & derivatives
Spermidine - chemistry
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Summary:The products formed in reactions of the square-planar platinum(II) anticancer complexes, [Pt(en)Cl(2)] and [Pt(R,R-dach)Cl(2)] where en=ethylenediamine and dach=diaminocyclohexane, with trypanothione, a glutathione analogue found in some parasites, and octreotide, a synthetic analogue of the hormone somatostatin, have been investigated. Mononuclear and binuclear platinum adducts were formed in reactions of the cyclic disulfides in their oxidised and reduced forms, and were analysed by UV-visible spectroscopy and liquid chromatography-mass spectrometry (LC-MS). NMR and molecular modelling studies were carried out on the mononuclear adducts.
ISSN:0162-0134
DOI:10.1016/j.jinorgbio.2006.08.011