The effect of streptomycin on stretch-induced electrophysiological changes of isolated acute myocardial infarcted hearts in rats

Aims To explore whether the stretch of ischaemic myocardium could modulate the electrophysiological characteristics, especially repolarization via mechanoelectric feedback (MEF), as well as the effect of streptomycin (SM) on these changes. Methods Thirty-six wistar rats were randomly divided into fo...

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Bibliographic Details
Published in:Europace (London, England) England), 2007-08, Vol.9 (8), p.578-584
Main Authors: Lu, Fu, Jun-xian, Cao, Rong-sheng, Xie, Jia, Li, Ying, Han, Li-qun, Zhu, Ying-nan, Dai
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Dose-Response Relationship, Drug
Heart - drug effects
Heart - physiopathology
Heart Conduction System - drug effects
Mechanotransduction, Cellular - drug effects
Myocardial Contraction - drug effects
Myocardial Infarction - physiopathology
Physical Stimulation - methods
Rats
Rats, Wistar
Streptomycin - administration & dosage
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Summary:Aims To explore whether the stretch of ischaemic myocardium could modulate the electrophysiological characteristics, especially repolarization via mechanoelectric feedback (MEF), as well as the effect of streptomycin (SM) on these changes. Methods Thirty-six wistar rats were randomly divided into four groups: control group (n = 9), SM group (n = 9), myocardial infarction (MI) group (n = 9), and MI + SM group (n = 9). After perfused on Langendorff, the isolated hearts were stretched for 5s by a ballon inflation of 0.2mL. After being stretched, the effect of the stretch was observed for 30s, including the 20, 20-70, 70, and 90% monophasic action potential duration (MAPD), i.e. MAPD20, MAPD20-70, MAPD70, and MAPD90, respectively, premature ventricular beats (PVB), and ventricular tachycardia (VT). Results The stretch caused a decrease in MAPD20-70 (both P
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/eum132