Protein dynamics and function: Insights from the energy landscape and solvent slaving

Protein motions are complex and a good way to describe them is in terms of a very high‐dimensional conformation space. We give here a simple explanation of the conformation space and the energy landscape, the conformational motions and protein reactions, based on an analogy to a traffic problem. The...

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Bibliographic Details
Published in:IUBMB life 2007, Vol.59 (8‐9), p.506-512
Main Authors: Frauenfelder, Hans, Fenimore, Paul W., Young, Robert D.
Format: Article
Language:English
Subjects:
conformation space
energy landscape
Models, Molecular
Protein Conformation
Protein Folding
Protein motions
Proteins - chemistry
Solvents - chemistry
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Summary:Protein motions are complex and a good way to describe them is in terms of a very high‐dimensional conformation space. We give here a simple explanation of the conformation space and the energy landscape, the conformational motions and protein reactions, based on an analogy to a traffic problem. The analogy provides insight into the slaving of protein processes to bulk solvent fluctuations, in both the native and unfolded states.
ISSN:1521-6543
1521-6551
DOI:10.1080/15216540701194113