Current Status of Allogeneic Stem Cell Transplantation for Treatment of Hematologic Malignancies

Bone marrow transplantation has evolved significantly over the past 40 years. The initial rationale of using donor bone marrow to guarantee a supply of hematopoietic stem cells uncontaminated by tumor remains a relevant principle today. However, the donor hematopoietic cells also exert an important...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2007-09, Vol.82 (3), p.325-329
Main Authors: Hart, D P, Peggs, K S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Hematologic Neoplasms - therapy
Humans
Leukemia - therapy
Lymphoma - therapy
Medical sciences
Multiple Myeloma - therapy
Pharmacology. Drug treatments
Stem Cell Transplantation - trends
Tissue Donors
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Summary:Bone marrow transplantation has evolved significantly over the past 40 years. The initial rationale of using donor bone marrow to guarantee a supply of hematopoietic stem cells uncontaminated by tumor remains a relevant principle today. However, the donor hematopoietic cells also exert an important immunological, therapeutic effect in the recipient. This synopsis will consider the balance of conditioning therapy intensity and immunological effect of allogeneic stem cell transplantation, informing the positioning of these approaches in current treatment algorithms. Clinical Pharmacology & Therapeutics (2007) 82, 325–329; doi:10.1038/sj.clpt.6100283; published online 18 July 2007
ISSN:0009-9236
1532-6535
DOI:10.1038/sj.clpt.6100283