Probing Structural Effects on Replication Efficiency through Comparative Analyses of Families of Potential Self-Replicators

A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self‐replication). In order to achieve this goal, a detailed underst...

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Bibliographic Details
Published in:Chemistry : a European journal 2006-11, Vol.12 (34), p.8798-8812
Main Authors: Kassianidis, Eleftherios, Pearson, Russell J., Philp, Douglas
Format: Article
Language:English
Subjects:
Catalysis
Chloroform - chemistry
Combinatorial Chemistry Techniques
Deuterium - chemistry
Dimerization
Furans - chemistry
Kinetics
Macromolecular Substances - chemistry
Magnetic Resonance Spectroscopy
Mathematics
Models, Chemical
molecular recognition
recognition-mediated reactions
self-replication
Stereoisomerism
supramolecular chemistry
Thermodynamics
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Summary:A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self‐replication). In order to achieve this goal, a detailed understanding of the relationship between molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally‐related systems reveals the key determinants that dictate the emergence of self‐replicative function and defines the structural space within which this behaviour is observed. Self‐replicating systems: Two diastereoisomeric cycloadducts Texo and Tendo (see graphic) are capable of acting as templates for their own formation, but not each other. Systematic variation of the template structure reveals that the structural window within which self‐replication can be observed is rather small for these systems.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200600460