Fibrous lipoblastoma with 8q11.2 abnormality

A 3-month-old African American female infant had a rapidly growing lipoblastoma with a prominent fibrous component in the soft tissue of the left lateral knee, which recurred at 10 months. Cytogenetic analysis revealed deletion of 8(q11.2q13) with a 19(q12q13.3) insertion at that site, confirming th...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2006-12, Vol.171 (2), p.112-114
Main Authors: Craver, Randall D., Henrich, Stephen, Kao, Yuan S.
Format: Article
Language:English
Subjects:
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Female
Humans
Infant
Knee
Neoplasm Recurrence, Local - genetics
Neoplasms, Adipose Tissue - genetics
Neoplasms, Adipose Tissue - pathology
Neoplasms, Fibrous Tissue - genetics
Neoplasms, Fibrous Tissue - pathology
Translocation, Genetic
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Summary:A 3-month-old African American female infant had a rapidly growing lipoblastoma with a prominent fibrous component in the soft tissue of the left lateral knee, which recurred at 10 months. Cytogenetic analysis revealed deletion of 8(q11.2q13) with a 19(q12q13.3) insertion at that site, confirming that this is closely related to the conventional lipoblastoma. The presence of multivacuolated lipoblasts and the staining characteristics (no staining for CD99, CD34, or smooth muscle actin) distinguish this from the recently described lipofibromatosis.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2006.06.020