Pharmacologic Treatment of Acute Kidney Injury: Why Drugs Haven’t Worked and What Is on the Horizon

Current strategies to limit the extent of injury in acute renal failure are based on extensive studies that identified cellular and molecular mechanisms of acute kidney injury. Despite successes in various animal models, translation to human studies has failed or studies are inconclusive. This revie...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2007-03, Vol.2 (2), p.356-365
Main Authors: Jo, Sang Kyung, Rosner, Mitchell H, Okusa, Mark D
Format: Article
Language:English
Subjects:
Acute Kidney Injury - drug therapy
Clinical Trials as Topic
Humans
Treatment Failure
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Summary:Current strategies to limit the extent of injury in acute renal failure are based on extensive studies that identified cellular and molecular mechanisms of acute kidney injury. Despite successes in various animal models, translation to human studies has failed or studies are inconclusive. This review describes past failures and barriers to successful clinical trials. It also focuses on promising preclinical studies using novel compounds that currently are in or close to human investigation. Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder.
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.03280906