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The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate Genes
Various studies have indicated that the human leukocyte antigen (HLA) region is associated with Hodgkin's lymphoma. We recently showed a specific association of the HLA class I region with EBV-positive Hodgkin's lymphoma cases. One haplotype of two consecutive microsatellite markers (D6S26...
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| Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2006-11, Vol.15 (11), p.2280-2284 |
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| container_end_page | 2284 |
| container_issue | 11 |
| container_start_page | 2280 |
| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | NIENS, Marijke VAN DEN BERG, Anke DIEPSTRA, Arjan NOLTE, Ilja M VAN DER STEEGE, Gerrit GALLAGHER, Alice TAYLOR, G. Malcolm JARRETT, Ruth F POPPEMA, Sibrand TE MEERMAN, Gerard J |
| description | Various studies have indicated that the human leukocyte antigen (HLA) region is associated with Hodgkin's lymphoma. We recently
showed a specific association of the HLA class I region with EBV-positive Hodgkin's lymphoma cases. One haplotype of two consecutive
microsatellite markers (D6S265 and D6S510) was overrepresented in the patient group, whereas another haplotype was underrepresented.
Here, we did fine mapping of this region of ∼400 kb as a next step to find the causative single-nucleotide polymorphism(s)
(SNP). To select candidate SNPs for screening the total study population, several known SNPs were determined by sequencing
two individuals homozygous for either of the above-mentioned associated haplotypes. Seven SNPs displayed different alleles
in these two individuals and were therefore analyzed in the total study population, including 238 Hodgkin's lymphoma patients
and 365 family-based controls. All seven SNPs showed significant association with the EBV-positive patient group. Two of these
SNPs were analyzed in a Scottish Hodgkin's lymphoma population and revealed significant associations as well. The associated
SNPs are located nearby two putative candidate genes: HLA-A and HLA complex group 9. HLA-A represents the most interesting target because of its consistent expression in EBV-positive Hodgkin's lymphoma cases and
its ability to present EBV-derived peptides to cytotoxic T cells. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2280–4) |
| doi_str_mv | 10.1158/1055-9965.EPI-06-0476 |
| format | article |
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showed a specific association of the HLA class I region with EBV-positive Hodgkin's lymphoma cases. One haplotype of two consecutive
microsatellite markers (D6S265 and D6S510) was overrepresented in the patient group, whereas another haplotype was underrepresented.
Here, we did fine mapping of this region of ∼400 kb as a next step to find the causative single-nucleotide polymorphism(s)
(SNP). To select candidate SNPs for screening the total study population, several known SNPs were determined by sequencing
two individuals homozygous for either of the above-mentioned associated haplotypes. Seven SNPs displayed different alleles
in these two individuals and were therefore analyzed in the total study population, including 238 Hodgkin's lymphoma patients
and 365 family-based controls. All seven SNPs showed significant association with the EBV-positive patient group. Two of these
SNPs were analyzed in a Scottish Hodgkin's lymphoma population and revealed significant associations as well. The associated
SNPs are located nearby two putative candidate genes: HLA-A and HLA complex group 9. HLA-A represents the most interesting target because of its consistent expression in EBV-positive Hodgkin's lymphoma cases and
its ability to present EBV-derived peptides to cytotoxic T cells. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2280–4)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-06-0476</identifier><identifier>PMID: 17119058</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Alleles ; Biological and medical sciences ; Case-Control Studies ; Chromosome Mapping ; EBV ; Genes, MHC Class I ; haplotype ; Haplotypes ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - metabolism ; HLA ; HLA-A Antigens - genetics ; Hodgkin ; Hodgkin Disease - genetics ; Hodgkin Disease - immunology ; Hodgkin Disease - virology ; Homozygote ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma - metabolism ; Medical sciences ; microsatellite ; Netherlands ; Peptides - chemistry ; Polymorphism, Single Nucleotide ; SNP ; T-Lymphocytes, Cytotoxic - immunology ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2006-11, Vol.15 (11), p.2280-2284</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-bea212b54ad11f3c812e478778562578857cfef8923bf585a560204f8dd69d743</citedby><cites>FETCH-LOGICAL-c402t-bea212b54ad11f3c812e478778562578857cfef8923bf585a560204f8dd69d743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18324161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17119058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NIENS, Marijke</creatorcontrib><creatorcontrib>VAN DEN BERG, Anke</creatorcontrib><creatorcontrib>DIEPSTRA, Arjan</creatorcontrib><creatorcontrib>NOLTE, Ilja M</creatorcontrib><creatorcontrib>VAN DER STEEGE, Gerrit</creatorcontrib><creatorcontrib>GALLAGHER, Alice</creatorcontrib><creatorcontrib>TAYLOR, G. Malcolm</creatorcontrib><creatorcontrib>JARRETT, Ruth F</creatorcontrib><creatorcontrib>POPPEMA, Sibrand</creatorcontrib><creatorcontrib>TE MEERMAN, Gerard J</creatorcontrib><title>The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate Genes</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Various studies have indicated that the human leukocyte antigen (HLA) region is associated with Hodgkin's lymphoma. We recently
showed a specific association of the HLA class I region with EBV-positive Hodgkin's lymphoma cases. One haplotype of two consecutive
microsatellite markers (D6S265 and D6S510) was overrepresented in the patient group, whereas another haplotype was underrepresented.
Here, we did fine mapping of this region of ∼400 kb as a next step to find the causative single-nucleotide polymorphism(s)
(SNP). To select candidate SNPs for screening the total study population, several known SNPs were determined by sequencing
two individuals homozygous for either of the above-mentioned associated haplotypes. Seven SNPs displayed different alleles
in these two individuals and were therefore analyzed in the total study population, including 238 Hodgkin's lymphoma patients
and 365 family-based controls. All seven SNPs showed significant association with the EBV-positive patient group. Two of these
SNPs were analyzed in a Scottish Hodgkin's lymphoma population and revealed significant associations as well. The associated
SNPs are located nearby two putative candidate genes: HLA-A and HLA complex group 9. HLA-A represents the most interesting target because of its consistent expression in EBV-positive Hodgkin's lymphoma cases and
its ability to present EBV-derived peptides to cytotoxic T cells. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2280–4)</description><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chromosome Mapping</subject><subject>EBV</subject><subject>Genes, MHC Class I</subject><subject>haplotype</subject><subject>Haplotypes</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - metabolism</subject><subject>HLA</subject><subject>HLA-A Antigens - genetics</subject><subject>Hodgkin</subject><subject>Hodgkin Disease - genetics</subject><subject>Hodgkin Disease - immunology</subject><subject>Hodgkin Disease - virology</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma - metabolism</subject><subject>Medical sciences</subject><subject>microsatellite</subject><subject>Netherlands</subject><subject>Peptides - chemistry</subject><subject>Polymorphism, Single Nucleotide</subject><subject>SNP</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkc2O0zAURiMEYn7gEUDeAGKRwXbi2GEXotJWikSFBraW69w0ZpI42AkzfRTeFocWzZLVvYvzffdKJ4peEXxDCBMfCGYszvOM3ax22xhnMU559iS6JCwRMeeMPQ37P-YiuvL-B8aY54w9jy4IJyTHTFxGv29bQJu5VwOqYL6z-jgBKobJHGBAZae8R1v0FQ7GDmjrUeG91UZNUKN7M7Vo9el7vLPeTOZXqLH14c4M7zyqjv3Y2l59RJuqiAukhnrZUGn7sYMHtHZ2HlGOCgdoN0_qb7wMlKlDN1rDAP5F9KxRnYeX53kdffu8ui03cfVlvS2LKtYpplO8B0UJ3bNU1YQ0iRaEQsoF54JllHEhGNcNNCKnyb5hgimWYYrTRtR1ltc8Ta6jt6fe0dmfM_hJ9sZr6Do1gJ29zAThmNHsvyDJ0zQNJwPITqB21nsHjRyd6ZU7SoLlIk8uYuQiRgZ5EmdykRdyr88H5n0P9WPqbCsAb86A8lp1jVODNv6REwlNSUYC9_7EtebQ3hsHUgcSnAMPyulWEhb-kJQKnPwBFS6ulA</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>NIENS, Marijke</creator><creator>VAN DEN BERG, Anke</creator><creator>DIEPSTRA, Arjan</creator><creator>NOLTE, Ilja M</creator><creator>VAN DER STEEGE, Gerrit</creator><creator>GALLAGHER, Alice</creator><creator>TAYLOR, G. Malcolm</creator><creator>JARRETT, Ruth F</creator><creator>POPPEMA, Sibrand</creator><creator>TE MEERMAN, Gerard J</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate Genes</title><author>NIENS, Marijke ; VAN DEN BERG, Anke ; DIEPSTRA, Arjan ; NOLTE, Ilja M ; VAN DER STEEGE, Gerrit ; GALLAGHER, Alice ; TAYLOR, G. 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Myelofibrosis</topic><topic>Lymphoma - metabolism</topic><topic>Medical sciences</topic><topic>microsatellite</topic><topic>Netherlands</topic><topic>Peptides - chemistry</topic><topic>Polymorphism, Single Nucleotide</topic><topic>SNP</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NIENS, Marijke</creatorcontrib><creatorcontrib>VAN DEN BERG, Anke</creatorcontrib><creatorcontrib>DIEPSTRA, Arjan</creatorcontrib><creatorcontrib>NOLTE, Ilja M</creatorcontrib><creatorcontrib>VAN DER STEEGE, Gerrit</creatorcontrib><creatorcontrib>GALLAGHER, Alice</creatorcontrib><creatorcontrib>TAYLOR, G. 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Malcolm</au><au>JARRETT, Ruth F</au><au>POPPEMA, Sibrand</au><au>TE MEERMAN, Gerard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate Genes</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>15</volume><issue>11</issue><spage>2280</spage><epage>2284</epage><pages>2280-2284</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Various studies have indicated that the human leukocyte antigen (HLA) region is associated with Hodgkin's lymphoma. We recently
showed a specific association of the HLA class I region with EBV-positive Hodgkin's lymphoma cases. One haplotype of two consecutive
microsatellite markers (D6S265 and D6S510) was overrepresented in the patient group, whereas another haplotype was underrepresented.
Here, we did fine mapping of this region of ∼400 kb as a next step to find the causative single-nucleotide polymorphism(s)
(SNP). To select candidate SNPs for screening the total study population, several known SNPs were determined by sequencing
two individuals homozygous for either of the above-mentioned associated haplotypes. Seven SNPs displayed different alleles
in these two individuals and were therefore analyzed in the total study population, including 238 Hodgkin's lymphoma patients
and 365 family-based controls. All seven SNPs showed significant association with the EBV-positive patient group. Two of these
SNPs were analyzed in a Scottish Hodgkin's lymphoma population and revealed significant associations as well. The associated
SNPs are located nearby two putative candidate genes: HLA-A and HLA complex group 9. HLA-A represents the most interesting target because of its consistent expression in EBV-positive Hodgkin's lymphoma cases and
its ability to present EBV-derived peptides to cytotoxic T cells. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2280–4)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17119058</pmid><doi>10.1158/1055-9965.EPI-06-0476</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2006-11, Vol.15 (11), p.2280-2284 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Alleles Biological and medical sciences Case-Control Studies Chromosome Mapping EBV Genes, MHC Class I haplotype Haplotypes Hematologic and hematopoietic diseases Herpesvirus 4, Human - metabolism HLA HLA-A Antigens - genetics Hodgkin Hodgkin Disease - genetics Hodgkin Disease - immunology Hodgkin Disease - virology Homozygote Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - metabolism Medical sciences microsatellite Netherlands Peptides - chemistry Polymorphism, Single Nucleotide SNP T-Lymphocytes, Cytotoxic - immunology Tumors |
| title | The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate Genes |
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