Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients

Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study wa...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2006-12, Vol.25 (6), p.897-905
Main Authors: Vaisman, Nachum, Haenen, Guido R.M.M., Zaruk, Yahalomit, Verduyn, Carin, Bindels, Jacques G., Verlaan, Sjors, Meijer, Erwin P.
Format: Article
Language:English
Subjects:
Aged
Antioxidants - administration & dosage
Antioxidants - metabolism
Biological and medical sciences
Carotenoids
Carotenoids - administration & dosage
Carotenoids - blood
Double-Blind Method
Enteral Nutrition
Enteral tube feeding
Female
Humans
Male
Malondialdehyde - blood
Medical sciences
Metabolic diseases
NF-kappa B
Nuclear Factor-kappaB
Nutritional Status
Oxidative stress
Oxidative Stress - drug effects
Time Factors
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Summary:Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study was to examine the effects of a low dose carotenoid mixture (3-mg/1500 kcal) for 3 months on serum carotenoid levels and oxidative stress in patients receiving long-term enteral nutrition as the sole source of nutrition. This randomized, double blind, controlled study compared patients receiving enteral nutrition with carotenoids ( N=26) and without carotenoids (control group; N=25). Patients on long-term enteral nutrition had low baseline serum carotenoid levels. Three months of enteral feeding enriched with carotenoids significantly ( P
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2006.06.002