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Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients
Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study wa...
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| Published in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2006-12, Vol.25 (6), p.897-905 |
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| cites | cdi_FETCH-LOGICAL-c384t-2fcaa7c2641a71d76cbde705e3d8ee14f2b0f873b77605388e10217d5222b8593 |
| container_end_page | 905 |
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| container_title | Clinical nutrition (Edinburgh, Scotland) |
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| creator | Vaisman, Nachum Haenen, Guido R.M.M. Zaruk, Yahalomit Verduyn, Carin Bindels, Jacques G. Verlaan, Sjors Meijer, Erwin P. |
| description | Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study was to examine the effects of a low dose carotenoid mixture (3-mg/1500
kcal) for 3 months on serum carotenoid levels and oxidative stress in patients receiving long-term enteral nutrition as the sole source of nutrition.
This randomized, double blind, controlled study compared patients receiving enteral nutrition with carotenoids (
N=26) and without carotenoids (control group;
N=25).
Patients on long-term enteral nutrition had low baseline serum carotenoid levels. Three months of enteral feeding enriched with carotenoids significantly (
P |
| doi_str_mv | 10.1016/j.clnu.2006.06.002 |
| format | article |
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kcal) for 3 months on serum carotenoid levels and oxidative stress in patients receiving long-term enteral nutrition as the sole source of nutrition.
This randomized, double blind, controlled study compared patients receiving enteral nutrition with carotenoids (
N=26) and without carotenoids (control group;
N=25).
Patients on long-term enteral nutrition had low baseline serum carotenoid levels. Three months of enteral feeding enriched with carotenoids significantly (
P<0.01) increased serum carotenoid levels compared with the control group. Oxidative stress as measured by NF-
κB levels was decreased at 3 months compared with the control group (
P<0.05). No significant changes in MDA levels were observed during the study period in either group.
This study demonstrated that enteral nutrition containing small amounts of carotenoids (3-mg/1500
kcal) in patients requiring long-term enteral feeding normalizes serum carotenoid levels to the lower end of the range found in age-matched controls. The NF-
κB data indicate a reduction in oxidative stress in these patients. Therefore, the use of formulas containing a mixture of carotenoids should be recommended for long-term enteral nutrition.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2006.06.002</identifier><identifier>PMID: 17052809</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Antioxidants - administration & dosage ; Antioxidants - metabolism ; Biological and medical sciences ; Carotenoids ; Carotenoids - administration & dosage ; Carotenoids - blood ; Double-Blind Method ; Enteral Nutrition ; Enteral tube feeding ; Female ; Humans ; Male ; Malondialdehyde - blood ; Medical sciences ; Metabolic diseases ; NF-kappa B ; Nuclear Factor-kappaB ; Nutritional Status ; Oxidative stress ; Oxidative Stress - drug effects ; Time Factors</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2006-12, Vol.25 (6), p.897-905</ispartof><rights>2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-2fcaa7c2641a71d76cbde705e3d8ee14f2b0f873b77605388e10217d5222b8593</citedby><cites>FETCH-LOGICAL-c384t-2fcaa7c2641a71d76cbde705e3d8ee14f2b0f873b77605388e10217d5222b8593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18340525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17052809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaisman, Nachum</creatorcontrib><creatorcontrib>Haenen, Guido R.M.M.</creatorcontrib><creatorcontrib>Zaruk, Yahalomit</creatorcontrib><creatorcontrib>Verduyn, Carin</creatorcontrib><creatorcontrib>Bindels, Jacques G.</creatorcontrib><creatorcontrib>Verlaan, Sjors</creatorcontrib><creatorcontrib>Meijer, Erwin P.</creatorcontrib><title>Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study was to examine the effects of a low dose carotenoid mixture (3-mg/1500
kcal) for 3 months on serum carotenoid levels and oxidative stress in patients receiving long-term enteral nutrition as the sole source of nutrition.
This randomized, double blind, controlled study compared patients receiving enteral nutrition with carotenoids (
N=26) and without carotenoids (control group;
N=25).
Patients on long-term enteral nutrition had low baseline serum carotenoid levels. Three months of enteral feeding enriched with carotenoids significantly (
P<0.01) increased serum carotenoid levels compared with the control group. Oxidative stress as measured by NF-
κB levels was decreased at 3 months compared with the control group (
P<0.05). No significant changes in MDA levels were observed during the study period in either group.
This study demonstrated that enteral nutrition containing small amounts of carotenoids (3-mg/1500
kcal) in patients requiring long-term enteral feeding normalizes serum carotenoid levels to the lower end of the range found in age-matched controls. The NF-
κB data indicate a reduction in oxidative stress in these patients. Therefore, the use of formulas containing a mixture of carotenoids should be recommended for long-term enteral nutrition.</description><subject>Aged</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carotenoids</subject><subject>Carotenoids - administration & dosage</subject><subject>Carotenoids - blood</subject><subject>Double-Blind Method</subject><subject>Enteral Nutrition</subject><subject>Enteral tube feeding</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>NF-kappa B</subject><subject>Nuclear Factor-kappaB</subject><subject>Nutritional Status</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Time Factors</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kU2LFDEQhoMo7rj6BzxILnrrMR_dnQx4kWX9gAUveg7ppHonQzo9ptKr61_wT5t2BtaTUBBIPVVvVb2EvORsyxnv3x62LqZlKxjrt2sw8YhseCdFw3daPiYbJnredD1vL8gzxANjrJNKPyUXXLFOaLbbkN_XqUC2kY4APqRbCikHtwdPf4Syp87muUCag0ea5jzZGH4B0rKHf1IUiy0LUps8zeAXV4n5Z_C2hDuoyQyINCQa53TbVLWpivwVjfdV1tNjBesPPidPRhsRXpzfS_Ltw_XXq0_NzZePn6_e3zRO6rY0YnTWKif6llvFverd4KEuBNJrAN6OYmCjVnJQqq8Law2cCa58J4QYdLeTl-TNqe8xz98XwGKmgA5itAnmBU2vuRJSqgqKE-jyjJhhNMccJpvvDWdmtcAczGqBWS0wazBRi16duy_DBP6h5HzzCrw-AxadjWO2yQV84LRsK9lV7t2Jg3qLuwDZoKt3ctWnDK4YP4f_zfEHo-6n6g</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Vaisman, Nachum</creator><creator>Haenen, Guido R.M.M.</creator><creator>Zaruk, Yahalomit</creator><creator>Verduyn, Carin</creator><creator>Bindels, Jacques G.</creator><creator>Verlaan, Sjors</creator><creator>Meijer, Erwin P.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients</title><author>Vaisman, Nachum ; Haenen, Guido R.M.M. ; Zaruk, Yahalomit ; Verduyn, Carin ; Bindels, Jacques G. ; Verlaan, Sjors ; Meijer, Erwin P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-2fcaa7c2641a71d76cbde705e3d8ee14f2b0f873b77605388e10217d5222b8593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carotenoids</topic><topic>Carotenoids - administration & dosage</topic><topic>Carotenoids - blood</topic><topic>Double-Blind Method</topic><topic>Enteral Nutrition</topic><topic>Enteral tube feeding</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>NF-kappa B</topic><topic>Nuclear Factor-kappaB</topic><topic>Nutritional Status</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaisman, Nachum</creatorcontrib><creatorcontrib>Haenen, Guido R.M.M.</creatorcontrib><creatorcontrib>Zaruk, Yahalomit</creatorcontrib><creatorcontrib>Verduyn, Carin</creatorcontrib><creatorcontrib>Bindels, Jacques G.</creatorcontrib><creatorcontrib>Verlaan, Sjors</creatorcontrib><creatorcontrib>Meijer, Erwin P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaisman, Nachum</au><au>Haenen, Guido R.M.M.</au><au>Zaruk, Yahalomit</au><au>Verduyn, Carin</au><au>Bindels, Jacques G.</au><au>Verlaan, Sjors</au><au>Meijer, Erwin P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>25</volume><issue>6</issue><spage>897</spage><epage>905</epage><pages>897-905</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><coden>CLNUDP</coden><abstract>Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study was to examine the effects of a low dose carotenoid mixture (3-mg/1500
kcal) for 3 months on serum carotenoid levels and oxidative stress in patients receiving long-term enteral nutrition as the sole source of nutrition.
This randomized, double blind, controlled study compared patients receiving enteral nutrition with carotenoids (
N=26) and without carotenoids (control group;
N=25).
Patients on long-term enteral nutrition had low baseline serum carotenoid levels. Three months of enteral feeding enriched with carotenoids significantly (
P<0.01) increased serum carotenoid levels compared with the control group. Oxidative stress as measured by NF-
κB levels was decreased at 3 months compared with the control group (
P<0.05). No significant changes in MDA levels were observed during the study period in either group.
This study demonstrated that enteral nutrition containing small amounts of carotenoids (3-mg/1500
kcal) in patients requiring long-term enteral feeding normalizes serum carotenoid levels to the lower end of the range found in age-matched controls. The NF-
κB data indicate a reduction in oxidative stress in these patients. Therefore, the use of formulas containing a mixture of carotenoids should be recommended for long-term enteral nutrition.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>17052809</pmid><doi>10.1016/j.clnu.2006.06.002</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2006-12, Vol.25 (6), p.897-905 |
| issn | 0261-5614 1532-1983 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Aged Antioxidants - administration & dosage Antioxidants - metabolism Biological and medical sciences Carotenoids Carotenoids - administration & dosage Carotenoids - blood Double-Blind Method Enteral Nutrition Enteral tube feeding Female Humans Male Malondialdehyde - blood Medical sciences Metabolic diseases NF-kappa B Nuclear Factor-kappaB Nutritional Status Oxidative stress Oxidative Stress - drug effects Time Factors |
| title | Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients |
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