Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery-Building chiral technology toolboxes

The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drug...

Full description

Saved in:
Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2007-09, Vol.19 (9), p.658-682
Main Authors: McConnell, Oliver, Bach II, Alvin, Balibar, Carl, Byrne, Neal, Cai, Yanxuan, Carter, Guy, Chlenov, Michael, Di, Li, Fan, Kristi, Goljer, Igor, He, Yanan, Herold, Don, Kagan, Michael, Kerns, Edward, Koehn, Frank, Kraml, Christina, Marathias, Vasilios, Marquez, Brian, McDonald, Leonard, Nogle, Lisa, Petucci, Christopher, Schlingmann, Gerhard, Tawa, Gregory, Tischler, Mark, Williamson, R. Thomas, Sutherland, Alan, Watts, William, Young, Mairead, Zhang, Mei-Yi, Zhang, Yingru, Zhou, Dahui, Ho, Douglas
Format: Article
Language:English
Subjects:
asymmetric transformations using enzymes
Chemistry, Pharmaceutical - methods
chiral liquid crystal NMR
chiral salt resolution
chiral separations
Chiral Technology
Chromatography - methods
Circular Dichroism
determination of absolute stereochemistry
Drug Design
Drug Industry - methods
electronic circular dichroism
Electrons
enantiomeric separations
exciton coupling
Humans
Magnetic Resonance Spectroscopy - methods
Models, Chemical
modified Mosher's or Trost NMR method
Molecular Conformation
optical rotation
Salts - pharmacology
Stereoisomerism
supercritical fluid chromatography
Technology, Pharmaceutical - methods
vibrational circular dichroism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drugs in the pharmaceutical industry. This has been due to the rapid increase over the past 10–15 years in potential drug candidates containing one or more asymmetric centers. Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral Technology tools, is provided. Chirality, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20399