Regulation of UV-induced DNA damage response by ubiquitylation

Like many other cellular processes, regulation of the DNA damage response (DDR) is regulated at different levels, ranging from transcriptional control to an array of distinct post-translational modifications. Involvement of ubiquitylation and the ubiquitin proteasome system in adjusting DDR are such...

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Bibliographic Details
Published in:DNA repair 2007-09, Vol.6 (9), p.1231-1242
Main Authors: Bergink, Steven, Jaspers, Nicolaas G.J., Vermeulen, Wim
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
DNA Damage - radiation effects
DNA damage response
DNA Repair - radiation effects
Fundamental and applied biological sciences. Psychology
Growth, nutrition, cell differenciation
Humans
Microbiology
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Nucleotide excision repair
Proteasome Endopeptidase Complex
Protein Processing, Post-Translational
Ubiquitin
Ubiquitin - metabolism
Ubiquitin-Protein Ligase Complexes - metabolism
Ultraviolet Rays
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Summary:Like many other cellular processes, regulation of the DNA damage response (DDR) is regulated at different levels, ranging from transcriptional control to an array of distinct post-translational modifications. Involvement of ubiquitylation and the ubiquitin proteasome system in adjusting DDR are such protein modifications that were receiving increasing attention in the field. In this review we summarize and discuss a few recent key publications addressing the issue of DDR factor ubiquitylation, focusing on UV-induced DDR. We discuss the implications of these modifications to allow swift adaptation and regulation of genome surveillance factors.
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2007.01.012