The threat of avian influenza A (H5N1). Part IV: Development of vaccines

Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine de...

Full description

Saved in:
Bibliographic Details
Published in:Medical microbiology and immunology 2007-12, Vol.196 (4), p.213-225
Main Authors: Cinatl, Jr, Jindrich, Michaelis, Martin, Doerr, Hans W
Format: Article
Language:English
Subjects:
Animals
Avian flu
Avian influenza virus
Birds
Clinical trials
Epidemiology
Humans
Immunology
Infectious diseases
Influenza A Virus, H5N1 Subtype - immunology
Influenza in Birds - epidemiology
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Pathology
Vaccines
Vaccines, DNA - immunology
Vaccines, Inactivated - immunology
Vaccines, Synthetic - immunology
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - immunology
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine development. Several phase I clinical studies with vaccines against H5 viruses have demonstrated limited efficacy compared to seasonal influenza vaccines. To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable.
ISSN:0300-8584
1432-1831
DOI:10.1007/s00430-007-0052-3