fMRI detection of early neural dysfunction in preclinical Huntington's disease

Neuropsychological and neuroimaging changes have been observed in individuals with the Huntington's disease (HD) gene expansion prior to the onset of manifest HD. This cross-sectional fMRI study of preclinical HD (pre-HD) individuals was conducted to determine if functional brain changes preced...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2007-09, Vol.13 (5), p.758-769
Main Authors: ZIMBELMAN, JANICE L., PAULSEN, JANE S., MIKOS, ANIA, REYNOLDS, NORMAN C., HOFFMANN, RAYMOND G., RAO, STEPHEN M.
Format: Article
Language:English
Subjects:
Adult
Basal ganglia
Brain
Brain - blood supply
Brain - pathology
Brain - physiopathology
Brain Mapping
Case-Control Studies
Changes
Clinical trials
Cross-Sectional Studies
Data analysis
Discrimination (Psychology) - physiology
Early detection
Female
Humans
Huntington Disease - pathology
Huntington Disease - physiopathology
Image Processing, Computer-Assisted - methods
Information processing
Magnetic Resonance Imaging
Male
Medical imaging
Methods
Neuropsychological Tests
Oxygen - blood
Studies
Time reproduction
Volumetric analysis
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Summary:Neuropsychological and neuroimaging changes have been observed in individuals with the Huntington's disease (HD) gene expansion prior to the onset of manifest HD. This cross-sectional fMRI study of preclinical HD (pre-HD) individuals was conducted to determine if functional brain changes precede deficits in behavioral performance and striatal atrophy. Twenty-six pre-HD and 13 demographically matched healthy participants performed a time reproduction task while undergoing fMRI scanning. Pre-HD participants were divided into two groups (n = 13 each): FAR (>12 years to estimated onset [YEO] of manifest HD) and CLOSE (
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617707071214