Effect of pregnancy on HIV disease progression and survival among women in rural Uganda

• Published in: Tropical medicine & international health 2007-08, Vol.12 (8), p.920-928
• Main Authors: Paal, Lieve Van der, Shafer, Leigh Anne, Mayanja, Billy N., Whitworth, Jimmy A. G., Grosskurth, Heiner
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antiretroviral drugs; Biological and medical sciences; CD4 Lymphocyte Count; Cohort Studies; conteo de linfocitos CD4; Disease Progression; embarazo; Female; General aspects; grossesse; HIV; HIV Infections - immunology; HIV Infections - mortality; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunology; Immunopathology; Infectious diseases; Medical sciences; Middle Aged; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - mortality; progresión de la enfermedad; progression de la maladie; Regression Analysis; Risk Factors; Rural areas; Rural Health; Survival Analysis; taux de lymphocyte CD4; Uganda - epidemiology; VIH; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Women
• ISSN: 1360-2276; 1365-3156
• DOI: 10.1111/j.1365-3156.2007.001873.x

Summary Objective  To investigate the effect of pregnancy on HIV disease progression and survival among HIV‐infected women in rural Uganda, prior to the introduction of anti‐retroviral therapy (ART). Methods  From a clinical cohort established in 1990, we selected records from HIV‐infected women of reproductive age. We conducted two analyses: (1) all HIV‐infected cases contributing to analysis of CD4 decline, using a linear regression model with random intercepts and slopes; (b) incident cases with known date of seroconversion contributed to analyses of median time to CD4