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Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma
d-Limonene shows carminative and cholagogue effects and is used in treatment of gallstone, cholecystitis and angiocholitis. A simple method was developed to determine the concentration of d-limonene in human plasma. d-Limonene and internal standard (naphthalane, C 10H 18) were extracted with n-hexan...
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| Published in: | Journal of pharmaceutical and biomedical analysis 2007-09, Vol.44 (5), p.1095-1099 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c384t-e57ae710e8cee96dce5eabbd6df3c8b92dbb272438ce571c99eba9ea1f70a1ec3 |
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| cites | cdi_FETCH-LOGICAL-c384t-e57ae710e8cee96dce5eabbd6df3c8b92dbb272438ce571c99eba9ea1f70a1ec3 |
| container_end_page | 1099 |
| container_issue | 5 |
| container_start_page | 1095 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 44 |
| creator | Wang, Shurong Chen, Yu Gao, Zhaoxia Xiong, Meijin Zhong, Zhirong Ye, Liming |
| description | d-Limonene shows carminative and cholagogue effects and is used in treatment of gallstone, cholecystitis and angiocholitis. A simple method was developed to determine the concentration of
d-limonene in human plasma.
d-Limonene and internal standard (naphthalane, C
10H
18) were extracted with
n-hexane and then injected to GC–MS. Calibration curves were linear (
r
=
0.9990,
n
=
6) in the range of 2–500
ng/ml for
d-limonene in human plasma. Limit of detection and quantification were 0.5 and 2
ng/ml, respectively. This rapid and specific method was applied to the clinical pharmacokinetic investigation of
d-limonene. |
| doi_str_mv | 10.1016/j.jpba.2007.04.018 |
| format | article |
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d-limonene in human plasma.
d-Limonene and internal standard (naphthalane, C
10H
18) were extracted with
n-hexane and then injected to GC–MS. Calibration curves were linear (
r
=
0.9990,
n
=
6) in the range of 2–500
ng/ml for
d-limonene in human plasma. Limit of detection and quantification were 0.5 and 2
ng/ml, respectively. This rapid and specific method was applied to the clinical pharmacokinetic investigation of
d-limonene.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2007.04.018</identifier><identifier>PMID: 17540528</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Analysis ; Analytical, structural and metabolic biochemistry ; Area Under Curve ; Biological and medical sciences ; Calibration ; Cyclohexenes - blood ; Cyclohexenes - chemistry ; Cyclohexenes - pharmacokinetics ; d-Limonene ; Drug Stability ; Freezing ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry - instrumentation ; Gas Chromatography-Mass Spectrometry - methods ; GC–MS ; General pharmacology ; Half-Life ; Human plasma ; Humans ; Male ; Medical sciences ; Metabolic Clearance Rate ; Molecular Structure ; Pharmacology. Drug treatments ; Reference Standards ; Sensitivity and Specificity ; Temperature ; Terpenes - blood ; Terpenes - chemistry ; Terpenes - pharmacokinetics ; Time Factors</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2007-09, Vol.44 (5), p.1095-1099</ispartof><rights>2007 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-e57ae710e8cee96dce5eabbd6df3c8b92dbb272438ce571c99eba9ea1f70a1ec3</citedby><cites>FETCH-LOGICAL-c384t-e57ae710e8cee96dce5eabbd6df3c8b92dbb272438ce571c99eba9ea1f70a1ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19005420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17540528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shurong</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Gao, Zhaoxia</creatorcontrib><creatorcontrib>Xiong, Meijin</creatorcontrib><creatorcontrib>Zhong, Zhirong</creatorcontrib><creatorcontrib>Ye, Liming</creatorcontrib><title>Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>d-Limonene shows carminative and cholagogue effects and is used in treatment of gallstone, cholecystitis and angiocholitis. A simple method was developed to determine the concentration of
d-limonene in human plasma.
d-Limonene and internal standard (naphthalane, C
10H
18) were extracted with
n-hexane and then injected to GC–MS. Calibration curves were linear (
r
=
0.9990,
n
=
6) in the range of 2–500
ng/ml for
d-limonene in human plasma. Limit of detection and quantification were 0.5 and 2
ng/ml, respectively. This rapid and specific method was applied to the clinical pharmacokinetic investigation of
d-limonene.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Cyclohexenes - blood</subject><subject>Cyclohexenes - chemistry</subject><subject>Cyclohexenes - pharmacokinetics</subject><subject>d-Limonene</subject><subject>Drug Stability</subject><subject>Freezing</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry - instrumentation</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>GC–MS</subject><subject>General pharmacology</subject><subject>Half-Life</subject><subject>Human plasma</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Standards</subject><subject>Sensitivity and Specificity</subject><subject>Temperature</subject><subject>Terpenes - blood</subject><subject>Terpenes - chemistry</subject><subject>Terpenes - pharmacokinetics</subject><subject>Time Factors</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kE1q3EAQhZvgEI-dXCCLoI2zk1IttdQSZBOGeGwweGODd02pVcr0oL90aQyzyx1yQ5_EPYzAO69q8b73KD4hvkpIJMjixy7ZTTUmKYBOQCUgyw9iJUudxWmhns7ECnQmYw1lfi4umHcAkMtKfRLnUucK8rRcifsNcmS3fuxxHv94nLbOvvz73yNzxBPZOSQ0e2cjHLA7sONobKMm7lw_DjRQ5IZou-9xiKYOucfP4mOLHdOX5V6Kx-vfD-ub-O5-c7v-dRfbrFRzTLlG0hKotERV0VjKCeu6KZo2s2VdpU1dpzpVWchzLW1VUY0VoWw1oCSbXYrvp93Jj3_3xLPpHVvqOhxo3LMpSqkLqVUA0xNo_cjsqTWTdz36g5FgjhrNzhw1mqNGA8oEjaH0bVnf1z01b5XFWwCuFgDZYtd6HKzjN64KqlUKgft54ii4eHbkDVtHg6XG-SDXNKN7749X_XWT-g</recordid><startdate>20070903</startdate><enddate>20070903</enddate><creator>Wang, Shurong</creator><creator>Chen, Yu</creator><creator>Gao, Zhaoxia</creator><creator>Xiong, Meijin</creator><creator>Zhong, Zhirong</creator><creator>Ye, Liming</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070903</creationdate><title>Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma</title><author>Wang, Shurong ; Chen, Yu ; Gao, Zhaoxia ; Xiong, Meijin ; Zhong, Zhirong ; Ye, Liming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-e57ae710e8cee96dce5eabbd6df3c8b92dbb272438ce571c99eba9ea1f70a1ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Cyclohexenes - blood</topic><topic>Cyclohexenes - chemistry</topic><topic>Cyclohexenes - pharmacokinetics</topic><topic>d-Limonene</topic><topic>Drug Stability</topic><topic>Freezing</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry - instrumentation</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>GC–MS</topic><topic>General pharmacology</topic><topic>Half-Life</topic><topic>Human plasma</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Standards</topic><topic>Sensitivity and Specificity</topic><topic>Temperature</topic><topic>Terpenes - blood</topic><topic>Terpenes - chemistry</topic><topic>Terpenes - pharmacokinetics</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shurong</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Gao, Zhaoxia</creatorcontrib><creatorcontrib>Xiong, Meijin</creatorcontrib><creatorcontrib>Zhong, Zhirong</creatorcontrib><creatorcontrib>Ye, Liming</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shurong</au><au>Chen, Yu</au><au>Gao, Zhaoxia</au><au>Xiong, Meijin</au><au>Zhong, Zhirong</au><au>Ye, Liming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2007-09-03</date><risdate>2007</risdate><volume>44</volume><issue>5</issue><spage>1095</spage><epage>1099</epage><pages>1095-1099</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>d-Limonene shows carminative and cholagogue effects and is used in treatment of gallstone, cholecystitis and angiocholitis. A simple method was developed to determine the concentration of
d-limonene in human plasma.
d-Limonene and internal standard (naphthalane, C
10H
18) were extracted with
n-hexane and then injected to GC–MS. Calibration curves were linear (
r
=
0.9990,
n
=
6) in the range of 2–500
ng/ml for
d-limonene in human plasma. Limit of detection and quantification were 0.5 and 2
ng/ml, respectively. This rapid and specific method was applied to the clinical pharmacokinetic investigation of
d-limonene.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17540528</pmid><doi>10.1016/j.jpba.2007.04.018</doi><tpages>5</tpages></addata></record> |
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| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68176174 |
| source | Elsevier |
| subjects | Adolescent Adult Analysis Analytical, structural and metabolic biochemistry Area Under Curve Biological and medical sciences Calibration Cyclohexenes - blood Cyclohexenes - chemistry Cyclohexenes - pharmacokinetics d-Limonene Drug Stability Freezing Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - instrumentation Gas Chromatography-Mass Spectrometry - methods GC–MS General pharmacology Half-Life Human plasma Humans Male Medical sciences Metabolic Clearance Rate Molecular Structure Pharmacology. Drug treatments Reference Standards Sensitivity and Specificity Temperature Terpenes - blood Terpenes - chemistry Terpenes - pharmacokinetics Time Factors |
| title | Gas chromatographic–mass spectrometric analysis of d-limonene in human plasma |
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