Cocaine and automaintained responding in pigeons: Rate-reducing effects and tolerance thereto with different CS–US pairing probabilities

To examine whether CS–US pairing probability, hence rate (or probability) of food delivery, modulated the effects of cocaine, pigeons were exposed to an autoshaping procedure in which 6-s red, green, and white illuminations of a response key were immediately followed by response-independent food del...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2007-10, Vol.87 (4), p.405-411
Main Authors: Porritt, Matthew, Arnold, Michelle, Poling, Alan
Format: Article
Language:English
Subjects:
Animals
Automaintenance
Autoshaping
Behavioral momentum
Biological and medical sciences
Cocaine
Cocaine - pharmacology
Columbidae
Conditioning, Operant - drug effects
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Drug Tolerance - physiology
Food
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Pigeons
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Reinforcement (Psychology)
Tolerance
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Summary:To examine whether CS–US pairing probability, hence rate (or probability) of food delivery, modulated the effects of cocaine, pigeons were exposed to an autoshaping procedure in which 6-s red, green, and white illuminations of a response key were immediately followed by response-independent food delivery with a probability of 1.0, 0.5, and 0.25, respectively. Substantial responding occurred at all probabilities. Pre- and post-chronic administrations of cocaine (1.0–17.8 mg/kg) produced dose-dependent decreases in mean percent trials (key illuminations) with a response and total responses per session at all probabilities. In general, sensitivity to the drug was lowest at the highest probability, suggesting that rate (or probability) of food delivery influenced the behavioral effects of cocaine.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2007.05.016