Conductometric evidence for intact polyion-induced liposome clusters

In this note, we present a set of electrical conductivity measurements of polyion-induced liposome aggregate aqueous suspensions that supports evidence for the existence of a cluster phase in low-density colloidal systems. Heavily NaCl-loaded liposomes, dispersed in a low-conductivity aqueous soluti...

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Bibliographic Details
Published in:Journal of colloid and interface science 2006-12, Vol.304 (2), p.512-517
Main Authors: Bordi, F., Cametti, C., Sennato, S., Viscomi, D.
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Chemistry
Colloidal state and disperse state
Conductometry - methods
Electrical conductivity
Exact sciences and technology
General and physical chemistry
Liposome
Liposome cluster
Membranes
Polyion-induced aggregation
Static Electricity
Unilamellar Liposomes - chemistry
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Summary:In this note, we present a set of electrical conductivity measurements of polyion-induced liposome aggregate aqueous suspensions that supports evidence for the existence of a cluster phase in low-density colloidal systems. Heavily NaCl-loaded liposomes, dispersed in a low-conductivity aqueous solution, are forced by electrostatic interactions with oppositely charged polyions to build up into individual aggregates, where the single vesicles maintain their integrity and, upon an external force, are able to release their ionic content. The conductivity data, within the effective medium approximation theory for heterogeneous systems, are in agreement with the picture of a suspension built up by clusters of vesicles which are able to preserve their content from the external medium. This finding opens new possibilities in multicompartment drug delivery techniques. The release of ion content: (c) Polyion-induced NaCl-loaded liposome aggregates. (d) Liposomes release their ionic content.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2006.09.009